Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …

Single-cell profiling methods have had a profound impact on the understanding of cellular
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level …

Efforts to sequence single protein molecules in nanopores,,,–have been hampered by the
lack of techniques with sufficient sensitivity to discern the subtle molecular differences …

The implementation of a reliable, rapid, inexpensive, and simple method for whole-proteome
identification would greatly benefit cell biology research and clinical medicine. Proteins are …

A high throughput single-molecule method for identifying peptides and sequencing proteins
based on nanopores could reduce costs and increase speeds of sequencing, allow the …

Nanopores in thin membranes play important roles in science and industry. Single
nanopores have provided a step-change in portable DNA sequencing and understanding …

Sequencing of nucleic acids with nanopores has emerged as a powerful tool offering rapid
readout, high accuracy, low cost and portability. This label-free method for sequencing at the …

Despite tremendous gains over the past decade, methods for characterizing proteins have
generally lagged behind those for nucleic acids, which are characterized by extremely high …

The advent of single-molecule probing techniques has revolutionized the biomedical and
life science fields and has spurred the development of a new class of labs-on-chip based on …

Successfully threading unfolded protein molecules through nanopores whose sizes are
comparable to that of an amino acid is a prerequisite for the nanopore-based protein …