Approach to sedation and analgesia in COVID-19 patients on venovenous extracorporeal membrane oxygenation

D Dreucean, JE Harris, P Voore… - Annals of …, 2022 - journals.sagepub.com
Objective: To describe clinically pertinent challenges of managing sedation in COVID-19
patients on venovenous extracorporeal membrane oxygenation (VV-ECMO) and describe …

Pharmacokinetics of commonly used medications in children receiving continuous renal replacement therapy: a systematic review of current literature

S Dubinsky, K Watt, S Saleeb, B Ahmed, C Carter… - Clinical …, 2022 - Springer
Abstract Background and Objective The use of continuous renal replacement therapy
(CRRT) for renal support has increased substantially in critically ill children compared with …

[HTML][HTML] Population pharmacokinetics in critically ill neonates and infants undergoing extracorporeal membrane oxygenation: a literature review

N Yalcin, N Sürmelioğlu, K Allegaert - BMJ Paediatrics Open, 2022 - ncbi.nlm.nih.gov
Extracorporeal membrane oxygenation (ECMO) increases circulating blood volume, causes
capillary leak and temporarily alters kidney function. Consequently, pharmacokinetics (PK) …

Meropenem Disposition in Neonatal and Pediatric Extracorporeal Membrane Oxygenation and Continuous Renal Replacement Therapy

P Pokorná, D Michaličková, D Tibboel, J Berner - Antibiotics, 2024 - mdpi.com
This study aimed to characterize the impact of extracorporeal membrane oxygenation
(ECMO) on the pharmacokinetics (PK) of meropenem in neonates and children and to …

Systematic Review of Ex Vivo and In Vivo Pharmacokinetic Studies of Drugs Commonly Used During Extracorporeal Membrane Oxygenation

A Dabirzadeh, E Decary, CN Fobisong… - ASAIO …, 2025 - journals.lww.com
Extracorporeal membrane oxygenation (ECMO) is a lifesaving treatment for critically ill
patients in cardiac or respiratory failure refractory to conventional treatment. Patients on an …

What is the best predictor of phenobarbital pharmacokinetics to use for initial dosing in neonates?

M Šíma, D Michaličková, O Slanař - Pharmaceutics, 2021 - mdpi.com
Phenobarbital is a first-line treatment of various seizure types in newborns. Dosage
individualization maximizing the proportion of patients with drug levels in therapeutic range …

Phenobarbital as a Sedation Strategy to Reduce Opioid and Benzodiazepine Burden in Neonatal Extracorporeal Membrane Oxygenation

VQ Cardona, E Byrne, M Mejia, S Joshi… - American journal of …, 2024 - thieme-connect.com
Objective The study aims to describe our experience with the implementation of
phenobarbital as a primary sedation strategy during neonatal extracorporeal membrane …

Sustaining Life versus Altering Life-Saving Drugs: Insights to Explain the Paradoxical Effect of Extracorporeal Membrane Oxygenation on Drugs

E Abidi, WS El Nekidy, B Atallah, K Al Zaman… - Journal of Clinical …, 2023 - mdpi.com
There has been a substantial increase in the use of extracorporeal membrane oxygenation
(ECMO) support in critically ill adults. Understanding the complex changes that could affect …

[PDF][PDF] Use of Physiologically-Based Pharmacokinetic Modelling To Support Dose Optimization in The Critically Ill

S Dubinsky - 2024 - uwspace.uwaterloo.ca
Critical care is a subspeciality of medicine that incorporates a multidisciplinary approach for
patient care in a heterogeneous population. The wide array of etiologies to critical illness …