Optogenetic techniques have been developed to allow control over the activity of selected
cells within a highly heterogeneous tissue, using a combination of genetic engineering and …

Single-cell sequencing technologies, including transcriptomic and epigenomic assays, are
transforming our understanding of the cellular building blocks of neural circuits. By directly …

Identification of the cis-regulatory elements controlling cell-type specific gene expression
patterns is essential for understanding the origin of cellular diversity. Conventional assays to …

INTRODUCTION In recent years, the single-cell genomics field has made incredible
progress toward disentangling the cellular heterogeneity of human tissues. However, the …

Adult cortical areas consist of specialized cell types and circuits that support unique higher-
order cognitive functions. How this regional diversity develops from an initially uniform …

The mammalian cerebrum performs high-level sensory perception, motor control and
cognitive functions through highly specialized cortical and subcortical structures. Recent …

The evolutionarily conserved default mode network (DMN) is a distributed set of brain
regions coactivated during resting states that is vulnerable to brain disorders. How disease …

Viral genetic tools that target specific brain cell types could transform basic neuroscience
and targeted gene therapy. Here, we use comparative open chromatin analysis to identify …

Enhancers are the primary DNA regulatory elements that confer cell type specificity of gene
expression. Recent studies characterizing individual enhancers have revealed their …

The primary motor cortex (M1) is essential for voluntary fine motor control and is functionally
conserved across mammals. Using high-throughput transcriptomic and epigenomic profiling …