The PDGF/PDGFR pathway as a drug target

N Papadopoulos, J Lennartsson - Molecular aspects of medicine, 2018 - Elsevier
Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration,
primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed …

Involvement of platelet‐derived growth factor ligands and receptors in tumorigenesis

CH Heldin, J Lennartsson… - Journal of internal …, 2018 - Wiley Online Library
Platelet‐derived growth factor (PDGF) isoforms and their receptors have important roles
during embryogenesis, particularly in the development of various mesenchymal cell types in …

Modified staging classification for pancreatic neuroendocrine tumors on the basis of the American Joint Committee on Cancer and European Neuroendocrine Tumor …

G Luo, A Javed, JR Strosberg, K Jin… - Journal of Clinical …, 2017 - ascopubs.org
Purpose The European Neuroendocrine Tumor Society (ENETS) and the American Joint
Committee on Cancer (AJCC) staging classifications are two widely used systems in …

The tumor microenvironment in neuroendocrine tumors: biology and therapeutic implications

M Cives, E Pelle, D Quaresmini, FM Rizzo… - …, 2019 - karger.com
Neuroendocrine tumors (NETs) include a heterogeneous group of malignancies arising in
the diffuse neuroendocrine system and characterized by indolent growth. Complex …

[HTML][HTML] PDGF-C and PDGF-D signaling in vascular diseases and animal models

E Folestad, A Kunath, D Wågsäter - Molecular aspects of medicine, 2018 - Elsevier
Members of the platelet-derived growth factor (PDGF) family are well known to be involved
in different pathological conditions. The cellular and molecular mechanisms induced by the …

Aptamer targeted therapy potentiates immune checkpoint blockade in triple-negative breast cancer

S Camorani, M Passariello, L Agnello… - Journal of Experimental …, 2020 - Springer
Background Triple-negative breast cancer (TNBC) is a uniquely aggressive cancer with high
rates of relapse due to resistance to chemotherapy. TNBC expresses higher levels of …

Neuropilins in the context of tumor vasculature

S Niland, JA Eble - International journal of molecular sciences, 2019 - mdpi.com
Neuropilin-1 and Neuropilin-2 form a small family of plasma membrane spanning receptors
originally identified by the binding of semaphorin and vascular endothelial growth factor …

Pancreatic cancer survival analysis defines a signature that predicts outcome

P Raman, R Maddipati, KH Lim, A Tozeren - PloS one, 2018 - journals.plos.org
Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in the
US. Despite multiple large-scale genetic sequencing studies, identification of predictors of …

15 years of paraganglioma: imaging and imaging-based treatment of pheochromocytoma and paraganglioma

F Castinetti, A Kroiss, R Kumar… - Endocrine-related …, 2015 - erc.bioscientifica.com
Although anatomic imaging to assess the precise localization of pheochromocytomas/
paragangliomas (PHEOs/PGLs) is unavoidable before any surgical intervention on these …

Can histogram analysis of MR images predict aggressiveness in pancreatic neuroendocrine tumors?

R De Robertis, B Maris, N Cardobi, P Tinazzi Martini… - European …, 2018 - Springer
Objectives To evaluate MRI derived whole-tumour histogram analysis parameters in
predicting pancreatic neuroendocrine neoplasm (panNEN) grade and aggressiveness …