Interleukins and associated cytokines serve as the means of communication for innate and
adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a …

Ischemic stroke after cerebral artery occlusion is one of the major causes of chronic disability
worldwide. Interleukins (ILs) play a bidirectional role in ischemic stroke through information …

Immunotherapy with checkpoint blockade induces rapid and durable immune control of
cancer in some patients and has driven a monumental shift in cancer treatment. Neoantigen …

Natural killer (NK) cells, a crucial component of the innate immune system, have long been
of clinical interest for their antitumor properties. Almost every aspect of NK cell immunity is …

Ubiquitin signaling is a conserved, widespread, and dynamic process in which protein
substrates are rapidly modified by ubiquitin to impact protein activity, localization, or stability …

Upregulation of programmed death ligand 1 (PD-L1) helps tumor cells escape from immune
surveillance, and therapeutic antibodies targeting PD-1/PD-L1 have shown better patient …

Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-
infected cells and tumor cells. They are particularly powerful for elimination of hematological …

A variety of therapies have been developed and used for the treatment of colon cancer,
however, the high mortality rate remains high and more effective strategies are still in urgent …

Metabolic reprograming toward aerobic glycolysis is a pivotal mechanism shaping immune
responses. Here we show that deficiency in NF-κB-inducing kinase (NIK) impairs glycolysis …

Natural killer (NK) cells exert critical roles in anti-tumor immunity but how their functions are
regulated by epitranscriptional modification (eg, N6-methyladenosine (m6A) methylation) is …