Genetically engineered mouse models have significantly contributed to our understanding of
cancer biology. They have proven to be useful in validating gene functions, identifying novel …

Lung cancer cell lines have made a substantial contribution to lung cancer translational
research and biomedical discovery. A systematic approach to initiating and characterizing …

Simple Summary The current article provides an overview of the significance of using
various mouse and zebrafish models in cancer research. In addition, this review discusses …

Genome editing technology is a technique for targeted genetic modifications, enabling the
knockout and addition of specific DNA fragments. This technology has been widely used in …

Background Nonsteroidal anti-inflammatory drugs (NSAIDs) have been proposed as
chemopreventive agents for many tumours; however, the mechanism responsible for their …

Cancer gender disparities have been observed for a variety of human malignancies. Thyroid
cancer is one such example where there is a dramatic difference in the incidence …

Purpose The aim of this study was to characterize a cell-based model for the molecular
study of hypoxia-inducible factor (HIF)-1α activity, in the context of hypoxia, by means of …

The poor prognosis for patients with high‐grade glioma is partly due to the invasion of tumor
cells into surrounding brain tissue. The goal of the present work was to develop a mouse …

The development of genetically marked animal tumour xenografts is an area of ongoing
research to enable easier and more reliable testing of cancer therapies. Genetically marked …

Noninvasive in vivo imaging offers a novel approach to preclinical studies opening the
possibility of investigating biological events in the spatiotemporal dimension (eg, in any …