Packaging of eukaryotic genome into chromatin is a major obstacle to cells encountering
DNA damage caused by external or internal agents. For maintaining genomic integrity, the …

Defective double-strand break (DSB) repair leads to genomic instabilities that may augment
carcinogenesis. DSBs trigger transient transcriptional silencing in the vicinity of …

Transcription has classically been considered a potential threat to genome integrity.
Collision between transcription and DNA replication machinery, and retention of DNA: RNA …

Investigation of the red bread mold that contaminated French bakeries nearly two centuries
ago has led to a wealth of discoveries that have impacted our understanding of genetic …

The conserved Notch pathway functions in diverse developmental and disease‐related
processes, requiring mechanisms to ensure appropriate target selection and gene activation …

In eukaryotes, repetitive DNA can become silenced de novo, either transcriptionally or post-
transcriptionally, by processes independent of strong sequence-specific cues. The …

During DNA replication, nucleosomes ahead of replication forks are disassembled to
accommodate replication machinery. Following DNA replication, nucleosomes are then …

RNA interference (RNAi) is a mechanism conserved in eukaryotes that represses gene
expression by means of small noncoding RNAs (sRNAs) of about 20 to 30 nucleotides (nt) …

RNAi is a conserved genome defense mechanism in eukaryotes that protects against
deleterious effects of transposons and viral invasion. Repetitive DNA loci are a major source …

Acetylation of histone H3 lysine 56 (H3K56) by the fungal-specific histone acetyltransferase
Rtt109 plays important roles in maintaining genome integrity and surviving DNA damage …