The nuclear receptors known as PPARs and LXRs are lipid-activated transcription factors
that have emerged as key regulators of lipid metabolism and inflammation. PPARs and …

Nuclear receptors (NRs) are master regulators of transcriptional programs that integrate the
homeostatic control of almost all biological processes. Their direct mode of ligand regulation …

Members of the nuclear receptor superfamily of ligand-dependent transcription factors carry
out vital cellular functions and are highly druggable therapeutic targets. Liver X receptors …

TLR-mediated induction of cholesterol 25-hydoxylase transcription in dendritic cells and
macrophages is dependent on IFN-α/IFN-β and signaling through INF-αR and STAT1. The …

Bacterial lung diseases are a major cause of morbidity and mortality both in
immunocompromised and in immunocompetent individuals. Neutrophil accumulation, a …

Communication between organs participates in most physiological and pathological events.
Owing to the importance of precise coordination among the liver and virtually all organs in …

Dyslipidemia, the condition of elevated serum triglycerides, elevated low-density lipoprotein
cholesterol, and/or low high-density lipoprotein cholesterol, is a public health problem of …

Mucociliary clearance (MCC) and submucosal glands are major components of airway
innate immunity that have impaired function in cystic fibrosis (CF). Although both of these …

Respiratory diseases including asthma and chronic obstructive pulmonary disease (COPD)
are characterised by excessive and persistent inflammation. Current treatments are often …

Liver X receptors (LXR) are members of the nuclear receptor family. As activated
transcription factors, their putative association with human diseases makes them promising …