Lynch syndrome (LS) is characterised by predisposition to colorectal, endometrial, and other
cancers and is caused by inherited pathogenic variants affecting the DNA mismatch repair …

Ovarian cancer (OC) is one of the leading causes of cancer-related deaths in women. Most
patients are diagnosed with advanced epithelial OC in their late 60s, and early-onset adult …

Purpose There are no internationally agreed upon clinical guidelines as to which women
with gynecological cancer would benefit from Lynch syndrome screening or how best to …

Importance Lynch syndrome is caused by dominantly inherited germline mutations that
predispose individuals to colorectal, endometrial, ovarian, and other cancers through …

Abstract Purpose of the Review To assess the most recent high-quality evidence for
endometrial cancer prevention strategies. Recent Findings Obesity is an established risk …

Simple Summary Carriers of Lynch syndrome (LS) have an increased risk for several types
of tumour, in particular bowel and uterine cancers. LS is caused by inheritance of a faulty …

Objective The role of mismatch repair (MMR) deficiency in ovarian cancer (OC)
pathogenesis and its association with other clinicopathologic features, such as microsatellite …

Ovarian cancer is the fourth most common cause of cancer‐related death in women in the
developed world, and one of the most heritable cancers. One of the most significant risk …

Ovarian cancer is one of the most common gynecologic cancers that has the highest
mortality rate. Endometrioid ovarian cancer, a distinct subtype of epithelial ovarian cancer, is …

Genetics has become an integral part of our specialty, informing prenatal diagnosis, fertility
investigations, the management of gynaecological cancers and many other aspects of …