Chronic stress is a risk factor for numerous aging-related diseases and has been shown to
shorten lifespan in humans and other social mammals. Yet how life stress causes such a …

Aging involves seemingly paradoxical changes in energy metabolism. Molecular damage
accumulation increases cellular energy expenditure, yet whole-body energy expenditure …

Health emerges from coordinated psychobiological processes powered by mitochondrial
energy transformation. But how do mitochondria regulate the multisystem responses that …

Life stress can shorten lifespan and increase risk for aging-related diseases, but the biology
underlying this phenomenon remains unclear. Here we assessed the effect of chronic stress …

Senescent neural progenitor cells have been identified in brain lesions of people with
progressive multiple sclerosis (PMS). However, their role in disease pathobiology and …

Telomere attrition is a hallmark of biological aging, contributing to cellular replicative
senescence. However, few studies have examined the determinants of telomere attrition in …

Emerging theories emphasize the crucial role of allostasis (anticipatory and adaptive
regulation of the body's biological processes) and interoception (integration, anticipation …

Background Elevated allostatic load (AL) has been associated with the risk and poor
prognosis of many chronic diseases. The association between AL and inflammatory bowel …

Chronic pain is a stressor that affects whole person functioning. Persistent and prolonged
activation of the body's stress systems without adequate recovery can result in measurable …

Objective Psychosocial stress is transduced into disease risk through energy-dependent
release of hormones from the HPA and SAM axes. The levels of glucocorticoid and …