TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by
a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative …

The correct duplication and transmission of genetic material to daughter cells is the primary
objective of the cell division cycle. DNA replication and chromosome segregation present …

Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

The shortening of human telomeres has two opposing effects during cancer development.
On the one hand, telomere shortening can exert a tumour-suppressive effect through the …

Genome sequencing has uncovered a new mutational phenomenon in cancer and
congenital disorders called chromothripsis. Chromothripsis is characterized by extensive …

Dividing cells that experience chromosome mis-segregation generate aneuploid daughter
cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes …

In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore,
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …

p53 has been studied intensively as a major tumour suppressor that detects oncogenic
events in cancer cells and eliminates them through senescence (a permanent non …

Upon massive DNA damage cells fail to undergo productive DNA repair and trigger the cell
death response. Resistance to cell death is linked to cellular transformation and …

Telomeres, the protective ends of linear chromosomes, shorten throughout an individual's
lifetime. Telomere shortening is proposed to be a primary molecular cause of aging. Short …