Cyclic nucleotides (cAMP, cGMP) play a major role in normal and pathologic signaling.
Beyond receptors, cyclic nucleotide phosphodiesterases;(PDEs) rapidly convert the cyclic …

Given that obesity and diabetes have been major public health concerns and that disease
morbidities have been rising continuously, effective treatment for these diseases is urgently …

Background In utero exposure to maternal hyperglycemia has been associated with an
increased risk for the development of chronic diseases in later life. These predispositions …

Background Obesity, one of the most common chronic health conditions worldwide, is a
multifactorial disease caused by complex genetic and environmental interactions. Several …

DNA methylation (DNAm) has been implicated in acute coronary syndrome (ACS), but the
causality remains unclear in cross-sectional studies. Here, we conduct a prospective …

Objective Numerous genetic variants from meta-analyses of observational studies and
GWAS were reported to be associated with migraine susceptibility. However, due to the …

Background Migraine is a neurovascular disease with recurrent headache attacks. A
polymorphism (rs2651899) of the PRDM16 gene, which is associated with migraine, was …

The positive regulatory domain containing 16 (PRDM16) gene is a dominant transcriptional
regulator that favors the “browning” of white adipocytes in rodents. Since the “browning” of …

Introduction Positive regulatory domain containing 16 (PRDM16) protein represents the key
regulator of brown adipose tissue (BAT) development. It induces brown fat phenotype and …

Migraine is regarded as the most common disease affecting human functioning. Migraine is
classified as the common type of primary headache disorder characterized by the “episodic …