Cancer stands in the frontline among leading killers worldwide and the annual mortality rate
is expected to reach 16.4 million by 2040. Humans suffer from about 200 different types of …

Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous in their clinical
behavior and require therapies specially tailored according to staging, grading, origin and …

Protein tyrosine phosphatases have been the focus of considerable research efforts aimed
at developing novel therapeutics; however, these targets are often characterized as being …

Streptomyces species are soil-dwelling bacteria that produce vast numbers of
pharmaceutically valuable secondary metabolites (SMs), such as antibiotics …

Background Direct cloning combined with heterologous expression of a secondary
metabolite biosynthetic gene cluster has become a useful strategy for production …

Tautomycetin (TMC) is a polyketide metabolite produced by Streptomyces sp. CK4412 and
Streptomyces griseochromogenes.[1] This intriguing molecule was previously shown to …

Satellite cells are well known as a postnatal skeletal muscle stem cell reservoir that under
injury conditions participate in repair. However, mechanisms controlling satellite cell …

SHP2 phosphatase is a positive transducer of growth factor and cytokine signaling. SHP2 is
also a bona fide oncogene; gain-of-function SHP2 mutations leading to increased …

Medullary thyroid cancer (MTC) is a relatively uncommon neuroendocrine tumor that arises
from the calcitonin-secreting parafollicular cells of the thyroid gland. Unfortunately, MTC …

This study aimed to explore the underlying molecular mechanisms of colorectal cancer
(CRC) using bioinformatics analysis. Using GSE4107 datasets downloaded from the Gene …