Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Chitosan as a machine for biomolecule delivery: A review

Z Mohammadi, M Eini, A Rastegari, MR Tehrani - Carbohydrate Polymers, 2021 - Elsevier
The major role of biomolecules in treatment of different diseases has been proven by
several studies. However, the main drawback in successful treatment by these molecules is …

Current development of nano-drug delivery to target macrophages

D Cai, W Gao, Z Li, Y Zhang, L Xiao, Y Xiao - Biomedicines, 2022 - mdpi.com
Macrophages are the most important innate immune cells that participate in various
inflammation-related diseases. Therefore, macrophage-related pathological processes are …

Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis

ML Kang, JE Kim, GI Im - Acta biomaterialia, 2016 - Elsevier
Dual drug delivery of drugs with different therapeutic effects in a single system is an effective
way to treat a disease. One of the main challenges in dual drug delivery is to control the …

Tumor targeting strategies for chitosan-based nanoparticles

X Zhang, X Yang, J Ji, A Liu, G Zhai - Colloids and Surfaces B …, 2016 - Elsevier
Currently, targeted nanoparticles (NPs) are rapidly being developed to overcome various
bottlenecks of antitumor agents, such as poor solubility in aqueous solution, poor …

Thiol Michael addition reaction: a facile tool for introducing peptides into polymer‐based gene delivery systems

Y Sun, H Liu, L Cheng, S Zhu, C Cai… - Polymer …, 2018 - Wiley Online Library
Polymers, as widely used non‐viral gene carriers, suffer from high cytotoxicity and relatively
low transfection efficiency. Such crucial drawbacks of polymers could be solved by …

[HTML][HTML] Nanoassemblies designed for efficient nuclear targeting

M Skowicki, S Tarvirdipour, M Kraus… - Advanced Drug Delivery …, 2024 - Elsevier
One of the key aspects of coping efficiently with complex pathological conditions is
delivering the desired therapeutic compounds with precision in both space and time …

[图书][B] Nanotechnology in drug delivery: fundamentals, design, and applications

S Bhatia - 2017 - taylorfrancis.com
This important new book provides the fundamental understanding of the peptide and protein
drug delivery systems with a special focus on their nanotechnology applications. Addressing …

Peptides conjugation on biomaterials: chemical conjugation approaches and their promoted multifunction for biomedical applications

J Kim, Y Choi, J Park, HY Lee, J Choi - Biotechnology and Bioprocess …, 2024 - Springer
Researchers have made significant efforts to attach peptides to various biomaterials,
resulting in diverse functionalities. By harnessing the advantages of peptides, functions such …

Advances in the targeting molecules modified chitosan-based nanoformulations

H Du, X Cai, G Zhai - Current Drug Targets, 2013 - ingentaconnect.com
Chitosan, a cationic polysaccharide, has prompted the continuous impetus for the
development of safe and effective drug delivery systems due to its unique properties such as …