Functions of the neocortex depend on its bidirectional communication with the thalamus, via
cortico-thalamo-cortical (CTC) loops. Recent work dissecting the synaptic connectivity in …

The thalamus is the major source of cortical inputs shaping sensation, action, and cognition.
Thalamic circuits are targeted by two major inhibitory systems: the thalamic reticular nucleus …

The thalamic reticular nucleus (TRN), the major source of thalamic inhibition, regulates
thalamocortical interactions that are critical for sensory processing, attention and cognition 1 …

Integrative brain functions depend on widely distributed, rhythmically coordinated
computations. Through its long-ranging connections with cortex and most senses, the …

The activity of the GABAergic neurons of the thalamic reticular nucleus (TRN) has long been
known to play important roles in modulating the flow of information through the thalamus and …

Current concepts of corticothalamic organization in the mammalian brain are mainly based
on sensory systems, with less focus on circuits for higher-order cognitive functions. In …

Thalamic oscillators contribute to both normal rhythms associated with sleep and anesthesia
and abnormal, hypersynchronous oscillations that manifest behaviorally as absence …

Most sensory information destined for the neocortex is relayed through the thalamus, where
considerable transformation occurs,. One means of transformation involves interactions …

Identification of mechanisms which increase deep sleep could lead to novel treatments
which promote the restorative effects of sleep. Here, we show that knockdown of the α3 …

Voltage-gated sodium channel (VGSC) mutations cause severe epilepsies marked by
intermittent, pathological hypersynchronous brain states. Here we present two mechanisms …