Time to test antibacterial therapy in Alzheimer's disease

F Panza, M Lozupone, V Solfrizzi, M Watling… - Brain, 2019 - academic.oup.com
Alzheimer's disease is associated with cerebral accumulation of amyloid-β peptide and
hyperphosphorylated tau. In the past 28 years, huge efforts have been made in attempting to …

[HTML][HTML] Infectious origin of Alzheimer's disease: Amyloid beta as a component of brain antimicrobial immunity

I Vojtechova, T Machacek, Z Kristofikova… - PLoS …, 2022 - journals.plos.org
The amyloid cascade hypothesis, focusing on pathological proteins aggregation, has so far
failed to uncover the root cause of Alzheimer's disease (AD), or to provide an effective …

[HTML][HTML] Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer

HM Ngô, Y Zhou, H Lorenzi, K Wang, TK Kim… - Scientific Reports, 2017 - nature.com
One third of humans are infected lifelong with the brain-dwelling, protozoan parasite,
Toxoplasma gondii. Approximately fifteen million of these have congenital toxoplasmosis …

[HTML][HTML] Polymicrobial infections in brain tissue from Alzheimer's disease patients

D Pisa, R Alonso, AM Fernández-Fernández… - Scientific Reports, 2017 - nature.com
Several studies have advanced the idea that the etiology of Alzheimer's disease (AD) could
be microbial in origin. In the present study, we tested the possibility that polymicrobial …

[HTML][HTML] Toxoplasma gondii alters NMDAR signaling and induces signs of Alzheimer's disease in wild-type, C57BL/6 mice

L Torres, SA Robinson, DG Kim, A Yan… - Journal of …, 2018 - Springer
Background Alzheimer's disease (AD) is a progressive neurodegenerative disease
associated with cognitive decline and complete loss of basic functions. The ubiquitous …

Is Toxoplasma gondii a potential risk factor for Alzheimer's disease? A systematic review and meta-analysis

TN Chegeni, S Sarvi, M Moosazadeh, M Sharif… - Microbial …, 2019 - Elsevier
Toxoplasmosis is a major public health concern due to neurotropic nature and role in the
development of mental and behavioral disorders. Alzheimer's disease (AD) is an important …

Toxoplasma gondii infection and risk of Parkinson and Alzheimer diseases: A systematic review and meta-analysis on observational studies

M Bayani, SM Riahi, N Bazrafshan, HR Gamble… - Acta tropica, 2019 - Elsevier
In the past decade, Toxoplasma gondii infection has been recognized as a potential risk for
many psychiatric and neurological disorders. We performed this systematic review and meta …

Alzheimer's disease and gastrointestinal microbiota; impact of Helicobacter pylori infection involvement

M Doulberis, G Kotronis, D Gialamprinou… - International Journal …, 2021 - Taylor & Francis
Background: Alzheimer disease (AD) is a leading cause of global burden with great impact
on societies. Although research is working intensively on promising therapy, the problem …

Persistent Toxoplasma Infection of the Brain Induced Neurodegeneration Associated with Activation of Complement and Microglia

Y Li, EG Severance, RP Viscidi, RH Yolken… - Infection and …, 2019 - Am Soc Microbiol
Toxoplasma gondii, a common neurotropic parasite, is increasingly being linked to
neuropsychiatric disorders, including schizophrenia, Alzheimer's disease, and Parkinson's …

[HTML][HTML] Genetic, transcriptome, proteomic, and epidemiological evidence for blood-brain barrier disruption and polymicrobial brain invasion as determinant factors in …

CJ Carter - Journal of Alzheimer's disease reports, 2017 - content.iospress.com
Diverse pathogens are detected in Alzheimer's disease (AD) brains. A bioinformatics survey
showed that AD genome-wide association study (GWAS) genes (localized in bone marrow …