Technical innovations in peritoneal dialysis (PD), now used widely for the long-term
treatment of ESRD, have significantly reduced therapy-related complications, allowing …

Post-surgical adhesions are common in almost all surgical areas and are associated with
significant rates of morbidity, mortality, and increased healthcare costs, especially when a …

Fibrosis is part of a tissue repair response to injury, defined as increased deposition of
extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of …

Lay summary Peritoneal dialysis (PD) uses the peritoneal membrane for dialysis. The
peritoneal membrane is a thin layer of tissue that lines the abdomen. The lining is used as a …

Fibroblasts differentiate into myofibroblasts by acquiring new contractile function. This is
important for tissue repair, but it also contributes to organ fibrosis. Platelet-derived growth …

Long-term peritoneal dialysis causes morphologic and functional changes in the peritoneal
membrane. Although mesothelial-mesenchymal transition of peritoneal mesothelial cells is a …

Peritoneal fibrosis is characterized by abnormal production of extracellular matrix proteins
leading to progressive thickening of the submesothelial compact zone of the peritoneal …

Myofibroblasts are the key players in extracellular matrix remodeling, a core phenomenon in
numerous devastating fibrotic diseases. Not only in organ fibrosis, but also the pivotal role of …

Peritoneal dialysis (PD) is a renal replacement therapy for patients with end-stage renal
disease that is equivalent to hemodialysis with respect to adequacy, mortality, and other …

Idiopathic pulmonary fibrosis is incurable, and its progression is difficult to control and thus
can lead to pulmonary deterioration. Pan-histone deacetylase inhibitors such as SAHA have …