Factors influencing the levothyroxine dose in the hormone replacement therapy of primary hypothyroidism in adults
P Caron, S Grunenwald, L Persani… - Reviews in Endocrine …, 2022 - Springer
Levothyroxine (LT4) is a safe, effective means of hormone replacement therapy for
hypothyroidism. Here, we review the pharmaceutical, pathophysiological and behavioural …
hypothyroidism. Here, we review the pharmaceutical, pathophysiological and behavioural …
Pathophysiological relevance of deiodinase polymorphism
The finding of deiodinase polymorphisms that can diminish thyroid hormone signaling
and/or disrupt normal cellular function opens the door to customized treatment of …
and/or disrupt normal cellular function opens the door to customized treatment of …
[HTML][HTML] Individualised requirements for optimum treatment of hypothyroidism: complex needs, limited options
R Hoermann, JEM Midgley, R Larisch… - Drugs in context, 2019 - ncbi.nlm.nih.gov
Levothyroxine (LT4) therapy has a long history, a well-defined pharmacological profile and a
favourable safety record in the alleviation of hypothyroidism. However, questions remain in …
favourable safety record in the alleviation of hypothyroidism. However, questions remain in …
[HTML][HTML] Iodothyronine deiodinases and reduced sensitivity to thyroid hormones
RM Paragliola, A Corsello, P Concolino… - Frontiers in Bioscience …, 2020 - imrpress.com
Iodothyronine deiodinases are selenoproteins that regulate thyroid hormone metabolism. Of
the three types of deiodinases, type 2 is the major regulator of intracellular triiodothyronine …
the three types of deiodinases, type 2 is the major regulator of intracellular triiodothyronine …
Integrative analysis of histomorphology, transcriptome and whole genome resequencing identified DIO2 gene as a crucial gene for the protuberant knob located on …
Y Deng, S Hu, C Luo, Q Ouyang, L Li, J Ma, Z Lin… - Bmc Genomics, 2021 - Springer
Background During domestication, remarkable changes in behavior, morphology,
physiology and production performance have taken place in farm animals. As one of the …
physiology and production performance have taken place in farm animals. As one of the …
Optimizing levothyroxine replacement: A precision dosage model for post-thyroidectomy patients
G Yang, J Pu, S Zhu, Y Shi, Y Yang, J Mao… - … Journal of General …, 2024 - Taylor & Francis
Background Thyroidectomy is commonly performed for benign or malignant thyroid tumors,
often resulting in hypothyroidism. Levothyroxine (LT4) supplementation is crucial to maintain …
often resulting in hypothyroidism. Levothyroxine (LT4) supplementation is crucial to maintain …
Ionic Levothyroxine Formulations: Synthesis, Bioavailability, and Cytotoxicity Studies
A Barreira, AFM Santos, M Dionísio, AR Jesus… - International Journal of …, 2023 - mdpi.com
Thyroid diseases affect a considerable portion of the population, with hypothyroidism being
one of the most commonly reported thyroid diseases. Levothyroxine (T4) is clinically used to …
one of the most commonly reported thyroid diseases. Levothyroxine (T4) is clinically used to …
Type 2 deiodinase p. Thr92Ala polymorphism does not affect the severity of obesity and weight loss after bariatric surgery
N Benenati, A Bufano, S Cantara, C Ricci… - Scientific Reports, 2022 - nature.com
A single nucleotide polymorphism in the Type 2 deiodinase (DIO2) gene (p. Thr92Ala) was
found to be associated with hypertension, type 2 diabetes mellitus (T2DM), insulin …
found to be associated with hypertension, type 2 diabetes mellitus (T2DM), insulin …
SNP rs11185644 in RXRA gene and SNP rs2235544 in DIO1 gene predict dosage requirements in a cross-sectional sample of hypothyroid patients
R AlEjielat, A Khaleel, YS Batarseh… - BMC Endocrine …, 2023 - Springer
Background and purpose Primary hypothyroidism due to abnormality in the thyroid gland is
the most common endocrine disease The recommended starting dose of levothyroxine …
the most common endocrine disease The recommended starting dose of levothyroxine …
Association of pharmacogenomic, clinical and behavioural factors with oral levothyroxine (LT-4) dose of hypothyroid patients in Sri Lanka: a matched case control …
SS Dalugodage, G Bowatte, C Antonypillai… - BMC Medical …, 2024 - Springer
Background Hypothyroidism is a common endocrine disorder that exerts a substantial
influence on people all over the world. Levothyroxine (LT-4) is the drug of choice for the …
influence on people all over the world. Levothyroxine (LT-4) is the drug of choice for the …