Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration

RJ Tower, E Busse, J Jaramillo, M Lacey, K Hoffseth… - Elife, 2022 - elifesciences.org
De novo limb regeneration after amputation is restricted in mammals to the distal digit tip.
Central to this regenerative process is the blastema, a heterogeneous population of lineage …

Mammalian digit tip regeneration: moving from phenomenon to molecular mechanism

GL Johnson, JA Lehoczky - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
In this review, we present the current state of knowledge surrounding mammalian digit tip
regeneration. We discuss the origin and formation of the blastema, a structure integral to …

Oxaloacetate enhances and accelerates regeneration in young mice by promoting proliferation and mineralization

J Jaramillo, C Taylor, R McCarley, M Berger… - Frontiers in Cell and …, 2023 - frontiersin.org
Cell metabolism coordinates the biochemical reactions that produce carbon and ATP in
order for the cell to proliferate, differentiate, and respond to environmental changes. Cell …

Microcomputed tomography staging of bone histolysis in the regenerating mouse digit

PD Ketcham, F Imholt, M Yan, HM Smith… - Wound Repair and …, 2023 - Wiley Online Library
Humans and mice have the ability to regenerate the distal digit tip, the terminal phalanx (P3)
in response to amputation. What distinguishes P3 regeneration from regenerative failure is …

Age-dependent changes in bone architecture, patterning, and biomechanics during skeletal regeneration

K Hoffseth, E Busse, J Jaramillo, J Simkin… - Frontiers in cell and …, 2021 - frontiersin.org
Mouse digit amputation provides a useful model of bone growth after injury, in that the injury
promotes intramembranous bone formation in an adult animal. The digit tip is composed of …

Evaluating differences in Young's Modulus of regenerated and uninjured mouse digit bone through microCT density-based calculation and nanoindentation testing

KF Hoffseth, E Busse, M Lacey, MC Sammarco - Journal of biomechanics, 2022 - Elsevier
The mouse digit tip amputation model is an excellent model of bone regeneration, but its
size and shape present an obstacle for biomechanical testing. As a result, assessing the …

Investigating the Role of Sensory Neurons in a Mouse Model of Multi-Tissue Regeneration

M Hoover - 2024 - atrium.lib.uoguelph.ca
Appendage regeneration varies drastically across vertebrate species. Some species, such
as urodele amphibians, are capable of complete limb regeneration, however mammals have …

Evaluating Differences in Elastic Modulus of Regenerated and Uninjured Mouse Digit Bone through microCT Density-Elasticity Calculation and Nanoindentation …

KF Hoffseth, E Busse, M Lacey, MC Sammarco - bioRxiv, 2021 - biorxiv.org
Bone is an essential, healing structure in vertebrates that ensures daily function. However,
the regenerative capacity of bone declines with age, compromising quality of life in the …

Research on the design of automatic image processing function for intelligent face management system

W Cai - Applied Mathematics and Nonlinear Sciences, 2023 - sciendo.com
Around the background of rapid development of intelligent technology, an efficient image
processing system oriented to the smart management of human faces is focused on. The …

Lineage restriction, cellular heterogeneity, and patterning during mammalian digit tip regeneration

GL Johnson - 2022 - search.proquest.com
Regeneration can be broadly defined as the renewal of biological structures. This occurs
over the lifetimes of all multicellular organisms as structures like epithelia are replaced by …