Comparative genomics of the neglected human malaria parasite Plasmodium vivax

JM Carlton, JH Adams, JC Silva, SL Bidwell, H Lorenzi… - Nature, 2008 - nature.com
The human malaria parasite Plasmodium vivax is responsible for 25–40% of the∼ 515
million annual cases of malaria worldwide. Although seldom fatal, the parasite elicits severe …

The pir multigene family of Plasmodium: antigenic variation and beyond

D Cunningham, J Lawton, W Jarra, P Preiser… - Molecular and …, 2010 - Elsevier
Multigene families are present on the telomeric and sub-telomeric regions of most
chromosomes of the malaria parasite, Plasmodium. The largest gene family identified so far …

Plasmodium vivax and the importance of the subtelomeric multigene vir superfamily

C Fernandez-Becerra, MM Yamamoto, RZN Vêncio… - Trends in …, 2009 - cell.com
Plasmodium vivax is responsible for more than 100 million clinical cases yearly. Unlike P.
falciparum, in which infected red blood cells cytoadhere via variant proteins, avoiding …

De Novo Assembly of a Field Isolate Genome Reveals Novel Plasmodium vivax Erythrocyte Invasion Genes

J Hester, ER Chan, D Menard… - PLoS neglected …, 2013 - journals.plos.org
Recent sequencing of Plasmodium vivax field isolates and monkey-adapted strains enabled
characterization of SNPs throughout the genome. These analyses relied on mapping short …

Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals

U Böhme, TD Otto, JA Cotton, S Steinbiss… - Genome …, 2018 - genome.cshlp.org
Avian malaria parasites are prevalent around the world and infect a wide diversity of bird
species. Here, we report the sequencing and analysis of high-quality draft genome …

Functional analysis of Plasmodium vivax VIR proteins reveals different subcellular localizations and cytoadherence to the ICAM‐1 endothelial receptor

M Bernabeu, FJ Lopez, M Ferrer… - Cellular …, 2012 - Wiley Online Library
The subcellular localization and function of variant subtelomeric multigene families in
Plasmodium vivax remain vastly unknown. Among them, the vir superfamily is putatively …

A Systems-Based Analysis of Plasmodium vivax Lifecycle Transcription from Human to Mosquito

SJ Westenberger, CM McClean… - PLoS neglected …, 2010 - journals.plos.org
Background Up to 40% of the world's population is at risk for Plasmodium vivax malaria, a
disease that imposes a major public health and economic burden on endemic countries …

Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes

NV Dharia, AT Bright… - Proceedings of the …, 2010 - National Acad Sciences
Plasmodium vivax causes 25–40% of malaria cases worldwide, yet research on this human
malaria parasite has been neglected. Nevertheless, the recent publication of the P. vivax …

Variant surface antigens of malaria parasites: functional and evolutionary insights from comparative gene family classification and analysis

C Frech, N Chen - BMC genomics, 2013 - Springer
Background Plasmodium parasites, the causative agents of malaria, express many variant
antigens on cell surfaces. Variant surface antigens (VSAs) are typically organized into large …

Rapid identification of malaria vaccine candidates based on α-helical coiled coil protein motif

V Villard, GW Agak, G Frank, A Jafarshad, C Servis… - PloS one, 2007 - journals.plos.org
To identify malaria antigens for vaccine development, we selected α-helical coiled coil
domains of proteins predicted to be present in the parasite erythrocytic stage. The …