Neutrophil-Mediated Phagocytosis of Staphylococcus aureus

KPM van Kessel, J Bestebroer… - Frontiers in …, 2014 - frontiersin.org
Initial elimination of invading Staphylococcus aureus from the body is mediated by
professional phagocytes. The neutrophil is the major phagocyte of the innate immunity and …

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

JF Fisher, S Mobashery - Chemical reviews, 2020 - ACS Publications
The biological diversity of the unicellular bacteria—whether assessed by shape, food,
metabolism, or ecological niche—surely rivals (if not exceeds) that of the multicellular …

Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity

D Gerlach, Y Guo, C De Castro, SH Kim, K Schlatterer… - Nature, 2018 - nature.com
Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent cause of difficult-to-treat,
often fatal infections in humans,. Most humans have antibodies against S. aureus, but these …

Wall teichoic acid in Staphylococcus aureus host interaction

R van Dalen, A Peschel, NM van Sorge - Trends in microbiology, 2020 - cell.com
Staphylococcus aureus is a major opportunistic human pathogen that frequently causes
disease in community and hospital settings. Nasal colonization is an important risk factor for …

Antibody–antibiotic conjugates: a novel therapeutic platform against bacterial infections

S Mariathasan, MW Tan - Trends in molecular medicine, 2017 - cell.com
Antibodies are potent components of the immune repertoire and have been successfully
exploited to treat bacterial infections. Recently an antibody–antibiotic conjugate (AAC) that …

Invasive Staphylococcus epidermidis uses a unique processive wall teichoic acid glycosyltransferase to evade immune recognition

Y Guo, X Du, J Krusche, C Beck, S Ali, A Walter… - Science …, 2023 - science.org
Staphylococcus epidermidis expresses glycerol phosphate wall teichoic acid (WTA), but
some health care–associated methicillin-resistant S. epidermidis (HA-MRSE) clones …

Intravenous senescent erythrocyte vaccination modulates adaptive immunity and splenic complement production

Y He, C Cheng, Y Liu, FM Chen, Y Chen, C Yang… - ACS …, 2023 - ACS Publications
Targeted delivery of vaccines to the spleen remains a challenge. Inspired by the
erythrophagocytotic process in the spleen, we herein report that intravenous administration …

Wall teichoic acid substitution with glucose governs phage susceptibility of Staphylococcus epidermidis

C Beck, J Krusche, A Notaro, A Walter, L Kränkel… - Mbio, 2024 - Am Soc Microbiol
The species-and clone-specific susceptibility of Staphylococcus cells for bacteriophages is
governed by the structures and glycosylation patterns of wall teichoic acid (WTA) …

An accessory wall teichoic acid glycosyltransferase protects Staphylococcus aureus from the lytic activity of Podoviridae

X Li, D Gerlach, X Du, J Larsen, M Stegger, P Kühner… - Scientific reports, 2015 - nature.com
Many Staphylococcus aureus have lost a major genetic barrier against phage infection,
termed clustered regularly interspaced palindromic repeats (CRISPR/cas). Hence, S. aureus …

Wall teichoic acid glycosylation governs Staphylococcus aureus nasal colonization

V Winstel, P Kühner, F Salomon, J Larsen, R Skov… - MBio, 2015 - Am Soc Microbiol
Nasal colonization by the human pathogen Staphylococcus aureus is a major risk factor for
hospital-and community-acquired infections. A key factor required for nasal colonization is a …