To identify novel cancer therapies, the tumor microenvironment (TME) has received a lot of
attention in recent years in particular with the advent of clinical successes achieved by …

The IL-1 family of cytokines consists of IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ.
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …

The synthesis and functionalization of iron oxide nanoparticles (IONPs) is versatile, which
has enhanced the interest in studying them as theranostic agents over recent years. As …

Cancer-associated fibroblasts (CAFs) are the most abundant stromal cells within the tumor
microenvironment (TME). They extensively communicate with the other cells. Exosome …

Abstract Interleukin-33 (IL-33) is a member of the IL-1 family of cytokines that is constitutively
expressed in the nucleus of epithelial, endothelial and fibroblast-like cells. Upon cell stress …

Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide,
and is largely refractory to current immunotherapeutic interventions. The lack of efficacy of …

Accumulating evidence suggests that Interleukin-33 (IL-33), a member of the IL-1 family, has
crucial roles in tissue homeostasis and repair, type 2 immunity, inflammation, and viral …

Colorectal cancer (CRC) continues to be one of the main causes of death from cancer
because patients progress unfavorably due to resistance to current therapies. Dysregulation …

Recurrence and treatment resistance are major causes of cancer-associated death. There
has been a growing interest in better understanding epithelial–mesenchymal transition …

The process of drug discovery and pre‐clinical testing is currently inefficient, expensive, and
time‐consuming. Most importantly, the success rate is unsatisfactory, as only a small …