Heavy metal and metalloid-induced reproductive toxicity

AG Mukherjee, UR Wanjari, K Renu, B Vellingiri… - Environmental …, 2022 - Elsevier
Heavy metals and metalloid exposure are among the most common factors responsible for
reproductive toxicity in human beings. Several studies have indicated that numerous metals …

Neurotoxicity of fine and ultrafine particulate matter: a comprehensive review using a toxicity pathway-oriented adverse outcome pathway framework

SJ Qin, QG Zeng, HX Zeng, SP Li, J Andersson… - Science of The Total …, 2024 - Elsevier
Abstract Fine particulate matter (PM 2.5) can cause brain damage and diseases. Of note,
ultrafine particles (UFPs) with an aerodynamic diameter less than or equal to 100 nm are a …

Comparative toxicogenomics database (CTD): update 2023

AP Davis, TC Wiegers, RJ Johnson… - Nucleic acids …, 2023 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) harmonizes
cross-species heterogeneous data for chemical exposures and their biological …

CTD tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental …

AP Davis, TC Wiegers, J Wiegers, B Wyatt… - Toxicological …, 2023 - academic.oup.com
The molecular mechanisms connecting environmental exposures to adverse endpoints are
often unknown, reflecting knowledge gaps. At the Comparative Toxicogenomics Database …

[HTML][HTML] The interplay of arsenic, silymarin, and NF-ĸB pathway in male reproductive toxicity: A review

AG Mukherjee, AV Gopalakrishnan - Ecotoxicology and Environmental …, 2023 - Elsevier
Arsenic toxicity is one of the most trending reasons for several malfunctions, particularly
reproductive toxicity. The exact mechanism of arsenic poisoning is a big question mark …

Heavy metal exposure: molecular pathways, clinical implications, and protective strategies

H Koyama, T Kamogashira, T Yamasoba - Antioxidants, 2024 - mdpi.com
Heavy metals are often found in soil and can contaminate drinking water, posing a serious
threat to human health. Molecular pathways and curation therapies for mitigating heavy …

Associating diethylhexyl phthalate to gestational diabetes mellitus via adverse outcome pathways using a network-based approach

T Zhang, S Wang, L Li, A Zhu, Q Wang - Science of The Total Environment, 2022 - Elsevier
Gestational diabetes mellitus (GDM) is a common pregnancy complication that is harmful to
both the woman and fetus. Several epidemiological studies have found that exposure to …

Transforming environmental health datasets from the Comparative Toxicogenomics Database into chord diagrams to visualize molecular mechanisms

B Wyatt, AP Davis, TC Wiegers, J Wiegers… - Frontiers in …, 2024 - frontiersin.org
In environmental health, the specific molecular mechanisms connecting a chemical
exposure to an adverse endpoint are often unknown, reflecting knowledge gaps. At the …

Integration of computational toxicology, toxicogenomics data mining, and omics techniques to unveil toxicity pathways

X Wang, F Li, J Chen, C Ji, H Wu - ACS Sustainable Chemistry & …, 2021 - ACS Publications
Growing numbers of synthetic chemicals have potential endocrine-disrupting effects and
cause potential ecological and health risks. However, the primary toxicity pathways and …

[HTML][HTML] Benzo [a] pyrene inhibits testosterone biosynthesis via NDUFA10-mediated mitochondrial compromise in mouse Leydig cells: Integrating experimental and in …

W Yang, H Cui, Z Chai, P Zou, F Shi, B Yang… - Ecotoxicology and …, 2022 - Elsevier
Abstract Benzo [a] pyrene (B [a] P), a representative of polycyclic aromatic hydrocarbons
(PAHs), is ubiquitously spread in the environment and showing deleterious impacts on male …