NDMA impurity in valsartan and other pharmaceutical products: Analytical methods for the determination of N-nitrosamines

MK Parr, JF Joseph - Journal of Pharmaceutical and Biomedical Analysis, 2019 - Elsevier
Batch recalls for valsartan containing pharmaceutical products in July 2018 initiated a
discussion on possible contaminations with N-nitrosodimethylamine (NDMA). It appeared …

Regulatory updates and analytical methodologies for nitrosamine impurities detection in sartans, ranitidine, nizatidine, and metformin along with sample preparation …

KM Shaik, B Sarmah, GS Wadekar… - Critical reviews in …, 2022 - Taylor & Francis
Nitrosamine impurities have been detected in various pharmaceutical products in recent
days. Various sartans, ranitidine, nizatidine, and metformin have been recalled from the …

[HTML][HTML] NDMA analytics in metformin products: comparison of methods and pitfalls

M Fritzsche, G Blom, J Keitel, A Goettsche… - European Journal of …, 2022 - Elsevier
Background For nearly three years, the concerns regarding trace levels of N-nitrosamines in
pharmaceuticals and the associated cancer risk have significantly expanded and are a …

[HTML][HTML] Development of GC-MS/MS Method for Simultaneous Estimation of Four Nitrosoamine Genotoxic Impurities in Valsartan

SR Tummala, KP Amgoth - Turkish Journal of Pharmaceutical …, 2022 - ncbi.nlm.nih.gov
Objectives: Recently, N-nitrosamines were unexpectedly detected in valsartan and other
generic sartan products. Taking into this account, we developed a sensitive and stable …

On the spectroscopic investigation of lipstick stains: Forensic trace evidence

V Sharma, A Bharti, R Kumar - Spectrochimica Acta Part A: Molecular and …, 2019 - Elsevier
In forensic science, lipsticks are considered as crucial trace evidence because it helps in the
linking of the criminal with the crime scene. In the present work, twenty-five lipstick samples …

Rapid and efficient high-performance liquid chromatography analysis of N-nitrosodimethylamine impurity in valsartan drug substance and its products

S Masada, G Tsuji, R Arai, N Uchiyama, Y Demizu… - Scientific reports, 2019 - nature.com
In July 2018, certain valsartan-containing drugs were voluntary recalled in Japan owing to
contamination with N-nitrosodimethylamine (NDMA), a probable human carcinogen. In this …

Determination of nine prohibited N-nitrosamines in cosmetic products by vortex-assisted dispersive liquid–liquid microextraction prior to gas chromatography-mass …

L Schettino, JL Benedé, A Chisvert - RSC advances, 2023 - pubs.rsc.org
An analytical method for the simultaneous determination of nine prohibited N-nitrosamines
in cosmetic products is presented. N-nitrosamines are banned compounds in cosmetic …

Differentiation of red lipsticks using the attenuated total reflection technique supported by two chemometric methods

M Gładysz, M Król, P Kościelniak - Forensic Science International, 2017 - Elsevier
The main challenge for the identification and differentiation of lipsticks for forensic purposes
is the fact that they have a similar chemical composition—in particular, samples of the same …

[HTML][HTML] QuEChERS-同位素稀释-气相色谱-串联质谱法测定动物源性食品中9 种N-亚硝胺类化合物

K Xiangyi, L ZHUANG, F Enhua, LIN Peng… - Chinese Journal of …, 2021 - ncbi.nlm.nih.gov
建立了同时测定动物源性食品中9 种N-亚硝胺类化合物的气相色谱-串联质谱分析方法。
当下动物源性食品中N-亚硝胺类化合物污染种类较多, 对人体危害较大, 但国标GB 5009.26 …

A salting out-acetonitrile homogeneous extraction coupled with gas chromatography–mass spectrometry method for the simultaneous determination of thirteen N …

H Dong, X Guo, Y Xian, H Luo, B Wang, Y Wu - Journal of Chromatography …, 2015 - Elsevier
A sensitive gas chromatography–mass spectrometry method was established for the
simultaneous determination of thirteen N-nitrosamines (NAs) in skin care cosmetics. The …