Pregnancy-PBPK models: how are biochemical and physiological processes integrated?
E Thépaut, C Brochot, K Chardon, S Personne… - Computational …, 2023 - Elsevier
Physiologically based pharmacokinetic (PBPK) modeling is used to predict the
pharmacokinetic behavior of xenobiotics in humans. During pregnancy, anatomical and …
pharmacokinetic behavior of xenobiotics in humans. During pregnancy, anatomical and …
Physiologically Based Pharmacokinetic Modeling of Small Molecules: How Much Progress Have We Made?
N Isoherranen - Drug Metabolism and Disposition, 2024 - Elsevier
Physiologically based pharmacokinetic (PBPK) models of small molecules have become
mainstream in drug development and in academic research. The use of PBPK models is …
mainstream in drug development and in academic research. The use of PBPK models is …
Advancing understanding of human variability through toxicokinetic modeling, in vitro-in vivo extrapolation, and new approach methodologies
The merging of physiology and toxicokinetics, or pharmacokinetics, with computational
modeling to characterize dosimetry has led to major advances for both the chemical and …
modeling to characterize dosimetry has led to major advances for both the chemical and …
[HTML][HTML] The environmental neuroactive chemicals list of prioritized substances for human biomonitoring and neurotoxicity testing: A database and high-throughput …
There is a diversity of chemicals to which humans are potentially exposed. Few of these
chemicals have linked human biomonitoring data, and most have very limited neurotoxicity …
chemicals have linked human biomonitoring data, and most have very limited neurotoxicity …
Invited Perspective: Uneven Progress Addressing Population Variability in Human Health Risk Assessment
WA Chiu - Environmental Health Perspectives, 2024 - ehp.niehs.nih.gov
Concentration-Response Assessment. Geneva, Switzerland: WHO/ICPS. https://apps. who.
int/iris/handle/10665/43294 [accessed 21 August 2023]. 2. Bhat VS, Meek MEB, Valcke M …
int/iris/handle/10665/43294 [accessed 21 August 2023]. 2. Bhat VS, Meek MEB, Valcke M …
[HTML][HTML] Developmental neurotoxicity evaluation of acrylamide based on in vitro to in vivo extrapolation by pregnancy PBTK modelling
Y Johansson, RA Awoga, A Forsby - Toxicology, 2024 - Elsevier
Acrylamide (ACR) is a known neurotoxicant that can pass the placenta and has been
detected in breast milk. Some in vivo and in vitro studies indicate that ACR exposure might …
detected in breast milk. Some in vivo and in vitro studies indicate that ACR exposure might …
From cohort to cohort: A Similar Mixture Approach (SMACH) to evaluate exposures to a mixture leading to thyroid-mediated neurodevelopmental effects using …
M Sapounidou, PL Andersson, M Leemans, JB Fini… - Toxics, 2023 - mdpi.com
Prenatal exposure to a mixture (MIX N) of eight endocrine-disrupting chemicals has been
associated with language delay in children in a Swedish pregnancy cohort. A novel …
associated with language delay in children in a Swedish pregnancy cohort. A novel …
[HTML][HTML] Investigating open access new approach methods (NAM) to assess biological points of departure: A case study with 4 neurotoxic pesticides
MH Silva - Current Research in Toxicology, 2024 - Elsevier
Open access new approach methods (NAM) in the US EPA ToxCast program and NTP
Integrated Chemical Environment (ICE) were used to investigate activities of four neurotoxic …
Integrated Chemical Environment (ICE) were used to investigate activities of four neurotoxic …
Enabling Transparent Toxicokinetic Modeling for Public Health Risk Assessment
Toxicokinetics describes the absorption, distribution, metabolism, and elimination of
chemicals by the body. Predictions from toxicokinetic models provide key information for …
chemicals by the body. Predictions from toxicokinetic models provide key information for …
In vitro and in silico approach methods for developmental neurotoxicity assessment: Examining acrylamide
Y Johansson - 2024 - diva-portal.org
Developmental neurotoxicity (DNT) is a branch of toxicology that examines the effects of
chemicals on the developing nervous system. Traditional methods for assessing DNT mainly …
chemicals on the developing nervous system. Traditional methods for assessing DNT mainly …