Fibrosis is characterized by excessive deposition of extracellular matrix components such as
collagen in tissues or organs. Fibrosis can develop in the heart, kidneys, liver, skin or any …

Aldosterone is one of the most essential hormones synthesized by the adrenal gland
because it regulates water and electrolyte balance. G protein–coupled estrogen receptor …

Background Estrogenic signals are suggested to have protection roles in the development of
colorectal cancer (CRC). The G protein-coupled estrogen receptor (GPER) has been …

The mineralocorticoid receptor (MR) belongs to the steroid hormone receptor family and
classically functions as a ligand-dependent transcription factor. It is involved in water …

Aldosterone is the most known mineralocorticoid hormone synthesized by the adrenal
cortex. The genomic pathway displayed by aldosterone is attributed to the mineralocorticoid …

The bicarbonate ion has a fundamental role in vital systems. Impaired bicarbonate transport
leads to various diseases, including immune disorders, cystic fibrosis, tumorigenesis, kidney …

Aldosterone induces relevant effects binding to the mineralcorticoid receptor (MR), which
acts as a ligand-gated transcription factor. Alternate mechanisms can mediate the action of …

Endothelial damage is a critical mediator of myocardial ischemia/reperfusion (I/R) injury.
HSPA12B is an endothelial-cell-specifically expressed heat shock protein. However, the …

Objective: Estrogen is indispensable in health and disease and mainly functions through its
receptors. The protection of the cardiovascular system by estrogen and its receptors has …

Astrocytes exert a wide variety of functions with paramount importance in brain physiology.
After injury or infection, astrocytes become reactive and they respond by producing a variety …