Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide
incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C …

High-mobility group box 1 protein (HMGB1), which previously was thought to function only
as a nuclear factor that enhances transcription, was recently discovered to be a crucial …

Acute-on-chronic liver failure (ACLF) has been recognized as a severe clinical syndrome
based on the acute deterioration of chronic liver disease and is characterized by organ …

Hepatitis B virus (HBV) infection is one the leading risk factors for chronic hepatitis, liver
fibrosis, cirrhosis and hepatocellular cancer (HCC), which are a major global health …

The template of hepatitis B virus (HBV) transcription, the covalently closed circular DNA
(cccDNA), plays a key role in the life-cycle of the virus and permits the persistence of …

Hepatitis B virus (HBV) chronically infects 250 million people worldwide, resulting in nearly
one million deaths annually. Studies in recent years have significantly improved our …

Chronic hepatitis B virus (HBV) infection is characterized by a weak immune response to
HBV. Regulatory T cells (Treg) can suppress the function of effector T cells and may thus be …

HBsAg seroclearance occurs rarely in the natural history of chronic hepatitis B (CHB)
infection and is associated with improved clinical outcomes. Many factors are associated …

Hepatitis B virus (HBV) is a major cause of chronic liver inflammation worldwide. Recent
knowledge of the virological and immunological events secondary to HBV infection has …

Despite significant reductions in morbidity and mortality secondary to availability of effective
combination anti‐retroviral therapy (cART), human immunodeficiency virus (HIV) infection …