Simple Summary In the last few years, an increasing number of genotype–phenotype
correlations has been described for neurofibromatosis type 1 (NF1), impacting on the clinical …

The diagnosis of a mediastinal mass may be challenging for clinicians, since lesions arising
within the mediastinum include a variety of disease entities, frequently requiring a …

Neurofibromatosis Type 1 (NF1) is a common genetic disorder and cancer predisposition
syndrome (1: 3000 births) caused by mutations in the tumor suppressor gene NF1. NF1 …

Many cancer cells rely on glutamine as the source of carbon molecules to feed the
biosynthetic pathways and are often addicted to glutaminolysis. Inhibitors of glutaminase …

Objective In this study, we review the institution's experience in treating malignant peripheral
nerve sheath tumors (MPNSTs). A secondary aim was to compare outcomes between …

Malignant peripheral nerve sheath tumors (MPNSTs) are soft-tissue sarcomas that
frequently arise in patients with neurofibromatosis type 1 (NF1). Most of these tumors are …

Malignant peripheral nerve sheath tumors (MPNSTs) are rare and aggressive soft tissue
sarcomas with a significant susceptibility to metastasize early in their course. Pathogenesis …

Abstract Neurofibromatosis type I (NF1), a monogenic disorder with an autosomal dominant
mode of inheritance, is caused by alterations in the NF1 gene which codes for the protein …

The cellular signaling pathways underlying peripheral nerve sheath tumor (PNST) formation
are poorly understood. Hippo signaling has been recently implicated in the biology of …

The neuromuscular junction (NMJ) is formed by motor nerve terminals, post-junctional
muscle membranes, and terminal Schwann cells (SCs). The formation of NMJ requires …