Metabotropic glutamate (mGlu) receptors were discovered in the mid 1980s and originally
described as glutamate receptors coupled to polyphosphoinositide hydrolysis. Almost 6500 …

Rationale l-Glutamate is the major excitatory neurotransmitter in the central nervous system
(CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor …

Metabotropic glutamate receptor 5 (mGluR5) is ubiquitously expressed in brain regions
responsible for memory and learning. It plays a key role in modulating rapid changes in …

Metabotropic (G-protein-coupled) glutamate (mGlu) receptors have now emerged as a
recognized, but still relatively new area of excitatory amino acid research. Current …

Fear conditioning is a valuable behavioral paradigm for studying the neural basis of
emotional learning and memory. The lateral nucleus of the amygdala (LA) is a crucial site of …

In the present paper we describe 2-methyl-6-(phenylethynyl)-pyridine (MPEP) as a potent,
selective and systemically active antagonist for the metabotropic glutamate receptor subtype …

NMDA receptors (NMDARs) play an important role in neural plasticity including long-term
potentiation and long-term depression, which are likely to explain their importance for …

(S)-Glutamic acid (Glu), which is the main excitatory neurotransmitter in the central nervous
system (CNS), and other excitatory amino acids (EAAs) operate through four different …

The group I specific metabotropic glutamate (mGlu) receptor agonist (RS)-3, 5-
dihydroxyphenylglycine (DHPG)(100 μM, 10 min) induced long-term depression (LTD) of …

In the mammalian brain, glutamate is regarded to be the primary excitatory neurotransmitter
due to its widespread distribution and wide range of metabolic functions. Glutamate plays …