The epidermis functions in skin as first defense line or barrier against environmental
impacts, resting on extracellular matrix (ECM) of the dermis underneath. Both compartments …

Basement membranes (BMs) are specialised extracellular matrix (ECM) structures and
collagens are a key component required for BM function. While collagen IV is the major BM …

Dystrophic epidermolysis bullosa (DEB) is one of the major types of EB, a rare hereditary
group of trauma-induced blistering skin disorders. DEB is caused by inherited pathogenic …

Splicing of pre‐messenger RNA into mature messenger RNA is an essential step for the
expression of most genes in higher eukaryotes. Defects in this process typically affect …

Epidermolysis bullosa (EB) is a heterogeneous group of rare inherited blistering skin
disorders characterized by skin fragility following minor trauma, usually present since birth …

Epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of inherited
blistering diseases that affects~ 500,000 people worldwide. Clinically, individuals with EB …

Epidermolysis bullosa (EB) is the umbrella term for a group of rare inherited skin fragility
disorders caused by mutations in at least 20 different genes. There is no cure for any of the …

Designer nucleases allow specific and precise genomic modifications and represent
versatile molecular tools for the correction of disease-associated mutations. In this study, we …

Dystrophic epidermolysis bullosa is a rare inherited blistering disorder caused by mutations
in the COL7A1 gene encoding type VII collagen. The deficiency and/or dysfunction of type …

The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system
induces site-specific double-strand breaks, which stimulate cellular DNA repair through …