Designing microbial cell factories for the production of chemicals

JS Cho, GB Kim, H Eun, CW Moon, SY Lee - Jacs Au, 2022 - ACS Publications
The sustainable production of chemicals from renewable, nonedible biomass has emerged
as an essential alternative to address pressing environmental issues arising from our heavy …

Systems metabolic engineering strategies: integrating systems and synthetic biology with metabolic engineering

KR Choi, WD Jang, D Yang, JS Cho, D Park… - Trends in …, 2019 - cell.com
Metabolic engineering allows development of microbial strains efficiently producing
chemicals and materials, but it requires much time, effort, and cost to make the strains …

Synthetic and systems biology for microbial production of commodity chemicals

V Chubukov, A Mukhopadhyay, CJ Petzold… - NPJ systems biology …, 2016 - nature.com
The combination of synthetic and systems biology is a powerful framework to study
fundamental questions in biology and produce chemicals of immediate practical application …

Tolerance engineering in bacteria for the production of advanced biofuels and chemicals

A Mukhopadhyay - Trends in microbiology, 2015 - cell.com
During microbial production of solvent-like compounds, such as advanced biofuels and bulk
chemicals, accumulation of the final product can negatively impact the cultivation of the host …

Biosynthesis of α-bisabolene from low-cost renewable feedstocks by peroxisome engineering and systems metabolic engineering of the yeast Yarrowia lipolytica

B Zhao, Y Zhang, Y Wang, Z Lu, L Miao, S Wang… - Green …, 2023 - pubs.rsc.org
Establishing efficient synthetic pathways for microbial production of biochemicals is often
hampered by competing pathways and insufficient precursor supply. Compartmentalization …

Strategies for enhancing microbial tolerance to inhibitors for biofuel production: a review

S Wang, X Sun, Q Yuan - Bioresource Technology, 2018 - Elsevier
Using lignocellulosic biomass for the production of renewable biofuel provides a sustainable
and promising solution to the crisis of energy and environment. However, the processes of …

Membrane transporter engineering in industrial biotechnology and whole cell biocatalysis

DB Kell, N Swainston, P Pir, SG Oliver - Trends in biotechnology, 2015 - cell.com
Because they mainly do not involve chemical changes, membrane transporters have been a
Cinderella subject in the biotechnology of small molecule production, but this is a serious …

Microbial response to environmental stresses: from fundamental mechanisms to practical applications

N Guan, J Li, H Shin, G Du, J Chen, L Liu - Applied microbiology and …, 2017 - Springer
Environmental stresses are usually active during the process of microbial fermentation and
have significant influence on microbial physiology. Microorganisms have developed a series …

Natural products as biofuels and bio-based chemicals: fatty acids and isoprenoids

HR Beller, TS Lee, L Katz - Natural product reports, 2015 - pubs.rsc.org
Covering: 2005 to 2015 Although natural products are best known for their use in medicine
and agriculture, a number of fatty acid-derived and isoprenoid natural products are being …

[HTML][HTML] Metabolic engineering for the high-yield production of isoprenoid-based C5 alcohols in E. coli

KW George, MG Thompson, A Kang, E Baidoo… - Scientific reports, 2015 - nature.com
Branched five carbon (C 5) alcohols are attractive targets for microbial production due to
their desirable fuel properties and importance as platform chemicals. In this study, we …