How innovations in methodology offer new prospects for volume electron microscopy

AJ Kievits, R Lane, EC Carroll… - Journal of …, 2022 - Wiley Online Library
Detailed knowledge of biological structure has been key in understanding biology at several
levels of organisation, from organs to cells and proteins. Volume electron microscopy …

[HTML][HTML] Impact of training data, ground truth and shape variability in the deep learning-based semantic segmentation of HeLa cells observed with electron microscopy

C Karabağ, MA Ortega-Ruíz, CC Reyes-Aldasoro - Journal of Imaging, 2023 - mdpi.com
This paper investigates the impact of the amount of training data and the shape variability on
the segmentation provided by the deep learning architecture U-Net. Further, the correctness …

[HTML][HTML] Beyond the surface: Investigation of tumorsphere morphology using volume electron microscopy

N Jadav, S Velamoor, D Huang, L Cassin… - Journal of Structural …, 2023 - Elsevier
The advent of volume electron microscopy (vEM) has provided unprecedented insights into
cellular and subcellular organization, revolutionizing our understanding of cancer biology …

[HTML][HTML] Online citizen science with the Zooniverse for analysis of biological volumetric data

P Smith, ONF King, A Pennington, W Tun… - Histochemistry and Cell …, 2023 - Springer
Public participation in research, also known as citizen science, is being increasingly
adopted for the analysis of biological volumetric data. Researchers working in this domain …

Morphomics via next-generation electron microscopy

R Son, K Yamazawa, A Oguchi, M Suga… - Journal of Molecular …, 2024 - academic.oup.com
The living body is composed of innumerable fine and complex structures. Although these
structures have been studied in the past, a vast amount of information pertaining to them still …

Evaluation of training data, ground truth and shape variability in the semantic segmentation of HeLa cells observed with electron microscopy

C Karabağ, CC Reyes-Aldasoro - bioRxiv, 2022 - biorxiv.org
This paper describes the quantitative and qualitative evaluation of training data, ground truth
and the variability of the shape of HeLa cells as observed with electron microscopy in the …

[PDF][PDF] Investigation of topological features of the 3D cellular nuclear envelope as observed with electron microscopy

K Dese, C Karabağ, P Giannopoulos… - 27th Conference on … - research.ed.ac.uk
Introduction The use of topological data analysis (TDA) in medical and biomedical
applications has been growing significantly [1],[2] and has provided interesting results in …