Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and
certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally …

The four types of platelet-derived growth factors (PDGFs) and the two types of PDGF
receptors (PDGFRs, which belong to class III receptor tyrosine kinases) have important …

Abstract Warrington, Janet A., Archana Nair, Mamatha Mahadevappa, and Maya
Tsyganskaya. Comparison of human adult and fetal expression and identification of 535 …

Many genes have been described and characterized which result in alternative
polyadenylation site use at the 3′-end of their mRNAs based on the cellular environment …

Anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin's lymphoma found in
children and young adults. ALCLs frequently carry a chromosomal translocation that results …

Breast cancer produces a variety of growth factors to promote its behavior at primary and
secondary sites in autocrine/paracrine manners. However, the role of these growth factors in …

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) represent one of the
most intensively studied families of growth factors in the last four decades. PDGF signaling …

Repair of tooth-supporting structures destroyed by the chronic inflammatory disease
periodontitis is a major goal of oral therapy. The field of tissue engineering combines …

It has become clear that a given cell type can qualitatively and quantitatively affect the
expression of the platelet-derived growth factor B (PDGF2/c-sis) gene at multiple levels. In a …

Idiopathic pulmonary fibrosis (IPF) is a deadly disease with a poor prognosis and few
treatment options. Pathological remodeling of the extracellular matrix (ECM) is a key factor …