Apolipoprotein E in cardiometabolic and neurological health and diseases

J Alagarsamy, A Jaeschke, DY Hui - International Journal of Molecular …, 2022 - mdpi.com
A preponderance of evidence obtained from genetically modified mice and human
population studies reveals the association of apolipoprotein E (apoE) deficiency and …

Insights into the roles of Apolipoprotein E in adipocyte biology and obesity

CL Jiang, FJ Lin - International Journal of Obesity, 2024 - nature.com
Apolipoprotein E (APOE) is a multifunctional protein expressed by various cell types,
including hepatocytes, adipocytes, immune cells of the myeloid lineage, vascular smooth …

Association of TERT (rs2736098 and rs2736100) genetic variants with elevated risk of hepatocellular carcinoma: a retrospective case–control study

WR Seif Eldin, EA Saad, A Monier, RM Elshazli - Scientific Reports, 2023 - nature.com
Hepatocellular carcinoma (HCC) is an inflammatory problematic issue with higher mortality
among different ethnic populations. The telomerase reverse transcriptase (TERT) gene has …

Unleash Multifunctional Role of miRNA Biogenesis Gene Variants (XPO5*rs34324334 and RAN*rs14035) with Susceptibility to Hepatocellular Carcinoma

MI Elsalahaty, AF Salama, T Diab, M Ghazy… - Journal of Personalized …, 2023 - mdpi.com
Numerous reports have explored the roles of different genetic variants in miRNA biogenesis
mechanisms and the progression of various types of carcinomas. The goal of this study is to …

The potential impact of CYP2D6 (* 2/* 4/* 10) gene variants among Egyptian epileptic children: a preliminary study

AM Elsaid, RF Zahran, SM Elmetwaly, Y Wahba… - Gene, 2022 - Elsevier
Abstract Background The cytochrome P450 (CYP) isoenzymes have an indispensable role
in the metabolic phase of different medications during the treatment of multiple …

Genetic variants of APEX1 p. Asp148Glu and XRCC1 p. Gln399Arg with the susceptibility of hepatocellular carcinoma

AM Saad, AES Abdel‐Megied, RA Elbaz… - Journal of Medical …, 2021 - Wiley Online Library
The DNA repair genes have a crucial function in the base excision repair (BER) mechanism
among different cancerous disorders, particularly hepatocellular carcinoma (HCC). The …

Association of ACE*(Insertion/Deletion) Variant with the Elevated Risk of Preeclampsia Among Gestational Women

EF El Azab, RG Abd El-kader, TM Elhassan… - Biochemical …, 2024 - Springer
The renin–angiotensin–aldosterone system has an indispensable function in the
uteroplacental circulation, placental growth, and blood pressure optimization. The …

Unraveling the molecular significance of CYP1A2 (rs762551; c.-9–154 C> A) genetic variant on breast carcinoma susceptibility: Insights from case-control study and …

AI Alalawy, MI Sakran, FM Alzuaibr, MA Alotaibi… - … -Research and Practice, 2024 - Elsevier
Background The human cytochrome P450 (CYP) superfamily encompasses different
categories of isoenzymes that contribute to multiple metabolic processes involving drug …

Association of DNA methylation and genetic variations of the APOE gene with the risk of diabetic dyslipidemia

S Ereqat, S Cauchi, K Eweidat… - Biomedical …, 2022 - spandidos-publications.com
Apolipoprotein E (APOE) is a key regulator of lipoprotein metabolism, and consequently,
affects the plasma and tissue lipid contents. The aim of the present study was to investigate …

[HTML][HTML] Correlation between genetic polymorphisms in apolipoprotein E and atrial fibrillation

Y Wang, H Lou, M Wang, J Mei, T Xing, F Wang… - Revista Portuguesa de …, 2022 - Elsevier
This work explores correlations between genetic polymorphisms in apolipoprotein E (ApoE)
and atrial fibrillation (AF). We detected polymorphisms in the APOE gene in 64 patients with …