Targeting oral tumor microenvironment for effective therapy

HS Budi, B Farhood - Cancer Cell International, 2023 - Springer
Oral cancers are among the common head and neck malignancies. Different anticancer
therapy modalities such as chemotherapy, immunotherapy, radiation therapy, and also …

Multi-organ landscape of therapy-resistant melanoma

S Liu, P Dharanipragada, SH Lomeli, Y Wang… - Nature medicine, 2023 - nature.com
Metastasis and failure of present-day therapies represent the most common causes of
mortality in patients with cutaneous melanoma. To identify the underlying genetic and …

Preoperative immunotherapy for head and neck cancers: state of art

AM Egloff, R Uppaluri - Current Opinion in Oncology, 2022 - journals.lww.com
Preoperative immunotherapy for head and neck cancers: state... : Current Opinion in Oncology
Preoperative immunotherapy for head and neck cancers: state of art : Current Opinion in Oncology …

[HTML][HTML] Neoadjuvant presurgical PD-1 inhibition in oral cavity squamous cell carcinoma

HM Knochelmann, JD Horton, S Liu, K Armeson… - Cell Reports …, 2021 - cell.com
Oral cavity squamous cell carcinoma (OCSCC) is a prevalent surgically treated subset of
head and neck cancer with frequent recurrence and poor survival. Immunotherapy has …

IL-33/ST2 signaling promotes constitutive and inductive PD-L1 expression and immune escape in oral squamous cell carcinoma

M Zhao, Y He, N Zhu, Y Song, Q Hu, Z Wang… - British Journal of …, 2023 - nature.com
Background Loss-of-function of PD-L1 induces therapy resistance of anti-PD-1/L1 therapy,
and the complex regulatory mechanisms are not completely understood. We previously …

Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti–PD-1 in head and neck cancer

G Oliveira, AM Egloff, AB Afeyan, JO Wolff, Z Zeng… - Science …, 2023 - science.org
About 50% of patients with locally advanced head and neck squamous cell carcinoma
(HNSCC) experience recurrences after definitive therapy. The presurgical administration of …

Next-generation sequencing identifies CDKN2A alterations as prognostic biomarkers in recurrent or metastatic head and neck squamous cell carcinoma …

L Xue, W Tang, J Zhou, J Xue, Q Li, X Ge, F Lin… - Frontiers in …, 2023 - frontiersin.org
Background This study aimed to identify potential biomarkers in patients with recurrent or
metastatic head and neck squamous cell carcinoma (HNSCC) and further probe the …

Immune checkpoint CD161/LLT1‐associated immunological landscape and diagnostic value in oral squamous cell carcinoma

X Hu, Y Dong, S Xie, Y Song, C Yu, Y He… - The Journal of …, 2024 - Wiley Online Library
An active host adaptive response is characterized by the existence of programmed cell
death protein 1 (PD‐1)+/IFN‐γ+ cytotoxic T cells and IFN‐γ‐induced PD‐L1+ tumor cells …

Integrative multi-omics analysis unveils stemness-associated molecular subtypes in prostate cancer and pan-cancer: prognostic and therapeutic significance

K Zheng, Y Hai, Y Xi, Y Zhang, Z Liu, W Chen… - Journal of Translational …, 2023 - Springer
Background Prostate cancer (PCA) is the fifth leading cause of cancer-related deaths
worldwide, with limited treatment options in the advanced stages. The immunosuppressive …

Personalised medicine and the potential role of electrospinning for targeted immunotherapeutics in head and neck cancer

CH O'Meara, TV Nguyen, Z Jafri, M Boyer… - Nanomaterials, 2023 - mdpi.com
Advanced head and neck cancer (HNC) is functionally and aesthetically destructive, and
despite significant advances in therapy, overall survival is poor, financial toxicity is high, and …