Neurotransmitters serve as chemical messengers playing a crucial role in information
processing throughout the nervous system, and are essential for healthy physiological and …

Schizophrenia remains a challenging disease to treat effectively with current antipsychotic
medications due to their limited efficacy across the entire spectrum of core symptoms as well …

Abstract Lynch, MA. Long-Term Potentiation and Memory. Physiol Rev 84: 87–136, 2004;
10.1152/physrev. 00014.2003.—One of the most significant challenges in neuroscience is to …

G-protein-coupled receptors (GPCRs) play critical roles in regulating brain function. Recent
advances have greatly expanded our understanding of these receptors as complex …

Although schizophrenia is an illness that has been historically characterized by the
presence of positive symptomatology, decades of research highlight the importance of …

Dr. Jacqueline N. Crawley, author of the First and Second Editions of What's Wrong with My
Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice, continues to field calls …

Deposition of amyloid-β (Aβ) in the brain can impair neuronal function and contribute to
cognitive decline in Alzheimer's disease (AD). Here, we found that dopamine and the …

Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransmitter
acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is …

Research during the last decade has significantly advanced our understanding of the
molecular mechanisms at the interface between the nervous system and the immune …

Cholinergic neurons are widespread, and pharmacological modulation of acetylcholine
receptors affects numerous brain processes, but such modulation entails side effects due to …