Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …

Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

Background Melatonin is an indole hormone secreted primarily by the pineal gland that
showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity. It can play an important …

Pro-inflammatory systemic conditions that can cause neuroinflammation and subsequent
alterations in brain regions involved in emotional regulation have been suggested as an …

Demyelination of the central nervous system (CNS) has been associated to reactive
microglia in neurodegenerative disorders, such as multiple sclerosis (MS). The M1 microglia …

Multiple sclerosis (MS) is a neurologic autoimmune disorder featured by chronic
inflammation of the central nervous system, demyelination and axonal damage. Recently …

Melatonin is a small natural compound, so called a neuro‐hormone that is synthesized
mainly in pineal gland in animals. Its main role is to master the clock of the body, under the …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS). While the etiology of MS is still largely unknown, scientists believe that the …

Previous studies revealed a latitudinal gradient of multiple sclerosis (MS) prevalence,
increasing by moving from the equator to the poles. The duration and quality of an …

Melatonin is a neurohormone mainly produced by the pineal gland following a circadian
rhythm. It is characterized as a pleiotropic factor because it not only regulates the wake …