Vibrational spectroscopy and imaging promise molecular information that can be rapidly
acquired without the need for specialized stains or dyes, thereby potentially simplifying and …

Current methods for cancer detection rely on tissue biopsy, chemical labeling/staining, and
examination of the tissue by a pathologist. Though these methods continue to remain the …

Tumor grade assessment is critical to the treatment of cancers. A pathologist typically
evaluates grade by examining morphologic organization in tissue using hematoxylin and …

Histological stains, such as hematoxylin and eosin (H&E), are routinely used in clinical
diagnosis and research. While these labels offer a high degree of specificity, throughput is …

Changes in the volume covered by mucin-secreting goblet cell regions within colon thin
sections may serve as a means to differentiate between ulcerative colitis and infectious …

Purpose Acute decompensated heart failure (ADHF) is the most prevalent cause of acute
respiratory distress worldwide, accounting for the majority of new cases and associated …

Acquiring comprehensive knowledge about the uptake of pollutants, impact on tissue
integrity and the effects at the molecular level in organisms is of increasing interest due to …

Tissue histology utilizing chemical and immunohistochemical labels plays an important role
in biomedicine and disease diagnosis. Recent research suggests that mid-infrared (IR) …

Abstract Background and Objective Multi-class cancer classification has been extensively
studied in digital and computational pathology due to its importance in clinical decision …

Digital analysis of cancer specimens using spectroscopic imaging coupled to machine
learning is an emerging area that links spatially localized spectral signatures to tissue …