RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond

SE Castel, RA Martienssen - Nature Reviews Genetics, 2013 - nature.com
A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in
addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm …

PIWI proteins and PIWI-interacting RNAs in the soma

RJ Ross, MM Weiner, H Lin - Nature, 2014 - nature.com
The discovery of millions of PIWI-interacting RNAs revealed a fascinating and unanticipated
dimension of biology. The PIWI–piRNA pathway has been commonly perceived as germline …

[HTML][HTML] Small RNAs as guardians of the genome

CD Malone, GJ Hannon - Cell, 2009 - cell.com
Transposons populate the landscape of all eukaryotic genomes. Often considered purely
genomic parasites, transposons can also benefit their hosts, playing roles in gene regulation …

[HTML][HTML] The centrality of RNA

PA Sharp - Cell, 2009 - cell.com
New roles for RNAs in biology continue to emerge, and a glance at the history of RNAs may
prepare molecular biologists for future discoveries about these powerful molecules. A …

The biogenesis and function of PIWI proteins and piRNAs: progress and prospect

T Thomson, H Lin - Annual Review of Cell and Developmental, 2009 - annualreviews.org
The evolutionarily conserved Argonaute/PIWI (AGO/PIWI, also known as PAZ-PIWI domain
or PPD) family of proteins is crucial for the biogenesis and function of small noncoding RNAs …

Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint

SG Gu, J Pak, S Guang, JM Maniar, S Kennedy… - Nature genetics, 2012 - nature.com
Exogenous double-stranded RNA (dsRNA) has been shown to exert homology-dependent
effects at the level of both target mRNA stability and chromatin structure. Using C. elegans …

[PDF][PDF] PIWI proteins and PIWI-interacting RNA: emerging roles in cancer

YN Han, Y Li, SQ Xia, YY Zhang, JH Zheng… - Cellular Physiology and …, 2018 - karger.com
P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding
RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the …

Programmed chromosome fragmentation in ciliated protozoa: multiple means to chromosome ends

M Bétermier, LA Klobutcher, E Orias - Microbiology and Molecular …, 2023 - Am Soc Microbiol
Ciliated protozoa undergo large-scale developmental rearrangement of their somatic
genomes when forming a new transcriptionally active macronucleus during conjugation …

Microarray Analyses of Gene Expression during the Tetrahymena thermophila Life Cycle

W Miao, J Xiong, J Bowen, W Wang, Y Liu… - PloS one, 2009 - journals.plos.org
Background The model eukaryote, Tetrahymena thermophila, is the first ciliated protozoan
whose genome has been sequenced, enabling genome-wide analysis of gene expression …

A domesticated piggyBac transposase plays key roles in heterochromatin dynamics and DNA cleavage during programmed DNA deletion in Tetrahymena …

CY Cheng, A Vogt, K Mochizuki… - Molecular biology of the …, 2010 - Am Soc Cell Biol
Transposons comprise large fractions of eukaryotic genomes and provide genetic reservoirs
for the evolution of new cellular functions. We identified TPB2, a homolog of the piggyBac …