A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in
addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm …

The discovery of millions of PIWI-interacting RNAs revealed a fascinating and unanticipated
dimension of biology. The PIWI–piRNA pathway has been commonly perceived as germline …

Transposons populate the landscape of all eukaryotic genomes. Often considered purely
genomic parasites, transposons can also benefit their hosts, playing roles in gene regulation …

New roles for RNAs in biology continue to emerge, and a glance at the history of RNAs may
prepare molecular biologists for future discoveries about these powerful molecules. A …

The evolutionarily conserved Argonaute/PIWI (AGO/PIWI, also known as PAZ-PIWI domain
or PPD) family of proteins is crucial for the biogenesis and function of small noncoding RNAs …

Exogenous double-stranded RNA (dsRNA) has been shown to exert homology-dependent
effects at the level of both target mRNA stability and chromatin structure. Using C. elegans …

P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding
RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the …

Ciliated protozoa undergo large-scale developmental rearrangement of their somatic
genomes when forming a new transcriptionally active macronucleus during conjugation …

Background The model eukaryote, Tetrahymena thermophila, is the first ciliated protozoan
whose genome has been sequenced, enabling genome-wide analysis of gene expression …

Transposons comprise large fractions of eukaryotic genomes and provide genetic reservoirs
for the evolution of new cellular functions. We identified TPB2, a homolog of the piggyBac …