Arginine methylation is an influential post-translational modification occurring on histones,
RNA binding proteins, and many other cellular proteins, affecting their function by altering …

Protein methyl transferases play critical roles in numerous regulatory pathways that underlie
cancer development, progression and therapy-response. Here we discuss the function of …

Posttranslational modification (PTM) of proteins is essential for increasing protein diversity
and maintaining cellular homeostasis, but uncontrolled modification may lead to …

The chromatin-associated protein WDR5 is a promising pharmacological target in cancer,
with most drug discovery efforts directed against an arginine-binding cavity in WDR5 called …

Abstract Protein arginine methyltransferase 5 (PRMT5) was discovered two decades ago.
The first decade focused on the biochemical characterization of PRMT5 as a regulator of …

Arginine methylation is a ubiquitous and relatively stable post-translational modification
(PTM) that occurs in three types: monomethylarginine (MMA), asymmetric dimethylarginine …

The epidemic of cardiovascular diseases (CVDs) is predicted to spread rapidly in advanced
countries accompanied by the high prevalence of risk factors. In terms of pathogenesis, the …

Histone arginine methylation is a key post-translational modification that mediates
epigenetic events that activate or repress gene transcription. Protein arginine …

Protein arginine methyltransferases (PRMTs) catalyze the post-translational
monomethylation (Rme1), asymmetric (Rme2a), or symmetric (Rme2s) dimethylation of …

Developmental proceedings and maintenance of cellular homeostasis are regulated by the
precise orchestration of a series of epigenetic events that eventually control gene …