Prodrugs have emerged as a major strategy for addressing clinical challenges by improving
drug pharmacokinetics, reducing toxicity, and enhancing treatment efficacy. The emergence …

Objective. Deep brain stimulation (DBS) is an established and valid therapy for a variety of
pathological conditions ranging from motor to cognitive disorders. Still, much of the DBS …

Deep brain stimulation of different targets has been shown to drastically improve symptoms
of a variety of neurological conditions. However, the occurrence of disabling side effects may …

Objective. Deep brain stimulation (DBS) is a growing treatment option for movement and
psychiatric disorders. As DBS technology moves toward directional leads with increased …

Periodically throughout history developments from adjacent fields of science and technology
reach a tipping point where together they produce unparalleled advances, such as the Allen …

Objective. Computational models are a popular tool for predicting the effects of deep brain
stimulation (DBS) on neural tissue. One commonly used model, the volume of tissue …

Neuroelectronic devices are critical for the diagnosis and treatment of neuropsychiatric
conditions, and are hypothesized to have many more applications. A wide variety of …

Implantable devices have provided various potential diagnostic options and therapeutic
methods in diverse medical fields. A variety of hard-material-based implantable electrodes …

A bidirectional brain interface with both “write” and “read” functions can be an important tool
for fundamental studies and potential clinical treatments for neurological diseases. Herein, a …

The synaptic organization of the brain is constantly modified by activity-dependent synaptic
plasticity. In several neurological disorders, abnormal neuronal activity and pathological …