Fungal secondary metabolism: regulation, function and drug discovery

NP Keller - Nature Reviews Microbiology, 2019 - nature.com
One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

Fungi as mediators linking organisms and ecosystems

M Bahram, T Netherway - FEMS Microbiology Reviews, 2022 - academic.oup.com
Fungi form a major and diverse component of most ecosystems on Earth. They are both
micro and macroorganisms with high and varying functional diversity as well as great …

The hidden power of secondary metabolites in plant-fungi interactions and sustainable phytoremediation

NA Elhamouly, OA Hewedy, A Zaitoon… - Frontiers in Plant …, 2022 - frontiersin.org
The global environment is dominated by various small exotic substances, known as
secondary metabolites, produced by plants and microorganisms. Plants and fungi are …

Bacterial–fungal interactions revealed by genome-wide analysis of bacterial mutant fitness

EC Pierce, M Morin, JC Little, RB Liu, J Tannous… - Nature …, 2021 - nature.com
Microbial interactions are expected to be major determinants of microbiome structure and
function. Although fungi are found in diverse microbiomes, their interactions with bacteria …

A call to arms: Mustering secondary metabolites for success and survival of an opportunistic pathogen

N Raffa, NP Keller - PLoS pathogens, 2019 - journals.plos.org
Aspergillus fumigatus is a ubiquitous saprophytic mold able to grow on a diversity of material
ranging from decayed organic matter in the environment to space station cupolas [1]. Yet this …

Role of quorum sensing and chemical communication in fungal biotechnology and pathogenesis

J Barriuso, DA Hogan, T Keshavarz… - FEMS microbiology …, 2018 - academic.oup.com
Microbial cells do not live in isolation in their environment, but rather they communicate with
each other using chemical signals. This sophisticated mode of cell-to-cell signalling, known …

Post‐translational modifications drive secondary metabolite biosynthesis in Aspergillus: a review

K Yang, J Tian, NP Keller - Environmental Microbiology, 2022 - Wiley Online Library
Post‐translational modifications (PTMs) are important for protein function and regulate
multiple cellular processes and secondary metabolites (SMs) in fungi. Aspergillus species …

Chemical signals driving bacterial–fungal interactions

S Khalid, NP Keller - Environmental Microbiology, 2021 - Wiley Online Library
Microorganisms reside in diverse environmental communities where interactions become
indispensable due to close physical associations. These interactions are driven by chemical …

The phc Quorum-Sensing System in Ralstonia solanacearum Species Complex

K Kai - Annual Review of Microbiology, 2023 - annualreviews.org
Ralstonia solanacearum species complex (RSSC) strains are devastating plant pathogens
distributed worldwide. The primary cell density–dependent gene expression system in …

Conserved responses in a war of small molecules between a plant-pathogenic bacterium and fungi

JE Spraker, P Wiemann, JA Baccile, N Venkatesh… - MBio, 2018 - Am Soc Microbiol
Small-molecule signaling is one major mode of communication within the polymicrobial
consortium of soil and rhizosphere. While microbial secondary metabolite (SM) production …