Modulation of endogenous cellular defense mechanisms via the vitagene system represents
an innovative approach to therapeutic intervention in diseases causing chronic tissue …

Skin, as the outermost organ of the body, is constantly exposed to both intrinsic and extrinsic
causative factors of aging. Intrinsic aging is related to compromised cellular proliferative …

SIRT1 is the most evolutionarily conserved mammalian sirtuin, and it plays a vital role in the
regulation of metabolism, stress responses, genome stability, and ageing. As a stress …

This article is directed at highlighting the involvement of the endogenous stress sensor
SIRT1 (silent information regulator T1) as a possible factor involved in hepatoprotection. The …

Fermentation can transform bioactive compounds in food and improve their biological
activity. This study aims to explore the transformation of polyphenols in mulberry juice and …

Abstract Sirtuin-1 (SIRT1) as a NAD+-dependent Class III protein deacetylase, involves in
longevity and various cellular physiological processes. SIRT1 via deacetylating transcription …

Sirtuins are a vast family of histone deacetylases, which are NAD+ dependent enzymes,
consisting of seven members, namely SIRT 1, SIRT 6 and SIRT 7 located within the nucleus …

The prevalence of various hepatic diseases increases dramatically worldwide and regarded
as a serious health problem. Sirtuins are one of the main strategic controllers of different …

Kidney injury is a relatively common complication of the use of aminoglycosides.
Inflammation and oxidative stress play a key role in gentamicin (GM) nephrotoxicity. We …

Neurodegenerative diseases might be slow but relentless, as we continue to fail in treating
or delaying their progression. Given the complexity in the pathogenesis of these diseases, a …