In vitro methods to assess drug precipitation
WG Dai - International Journal of Pharmaceutics, 2010 - Elsevier
Drug precipitation in vivo is often an undesirable outcome after administration of a drug
formulation into a human body. It may reduce drug concentration for immediate action …
formulation into a human body. It may reduce drug concentration for immediate action …
Prediction of Modified Release Pharmacokinetics and Pharmacodynamics from In Vitro, Immediate Release, and Intravenous Data
V Lukacova, WS Woltosz, MB Bolger - The AAPS journal, 2009 - Springer
The aim of this study was to demonstrate the value of mechanistic simulations in gaining
insight into the behaviors of modified release (MR) formulations in vivo and to use the …
insight into the behaviors of modified release (MR) formulations in vivo and to use the …
A pH-dilution method for estimation of biorelevant drug solubility along the gastrointestinal tract: application to physiologically based pharmacokinetic modeling
Y Gao, RA Carr, JK Spence, WW Wang… - Molecular …, 2010 - ACS Publications
Physiologically based pharmacokinetic (PBPK) modeling tools have become an integral part
of the modern drug discovery− development process. However, accurate PK prediction of …
of the modern drug discovery− development process. However, accurate PK prediction of …