Therapeutic strategies of dual-target small molecules to overcome drug resistance in cancer therapy
J Ye, J Wu, B Liu - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Despite some advances in targeted therapeutics of human cancers, curative cancer
treatment still remains a tremendous challenge due to the occurrence of drug resistance. A …
treatment still remains a tremendous challenge due to the occurrence of drug resistance. A …
Quinoline-based molecules targeting c-Met, EGF, and VEGF receptors and the proteins involved in related carcinogenic pathways
The quinoline ring system has long been known as a versatile nucleus in the design and
synthesis of biologically active compounds. Currently, more than one hundred quinoline …
synthesis of biologically active compounds. Currently, more than one hundred quinoline …
Structural optimization towards promising β-methyl-4-acrylamido quinoline derivatives as PI3K/mTOR dual inhibitors for anti-cancer therapy: The in vitro and in vivo …
R He, B Xu, L Ping, X Lv - European Journal of Medicinal Chemistry, 2021 - Elsevier
Built upon the 4-acrylamido quinoline derivative 4, a previously discovered PI3K/mTOR dual
inhibitor, structural modification was undertaken in this study with the attempt to improve its …
inhibitor, structural modification was undertaken in this study with the attempt to improve its …
Discovery of novel quinoline-based analogues of combretastatin A-4 as tubulin polymerisation inhibitors with apoptosis inducing activity and potent anticancer effect
TS Ibrahim, MM Hawwas, AM Malebari… - Journal of Enzyme …, 2021 - Taylor & Francis
A new series of quinoline derivatives of combretastatin A-4 have been designed,
synthesised and demonstrated as tubulin polymerisation inhibitors. These novel compounds …
synthesised and demonstrated as tubulin polymerisation inhibitors. These novel compounds …
Design, synthesis and antitumor effects of novel benzimidazole derivatives as PI3K inhibitors
W Wu, S Li, J Chen, T Duo, C Ma - Bioorganic & Medicinal Chemistry …, 2023 - Elsevier
Abstract Blocking the PI3K/Akt pathway has been widely recognized as an attractive cancer
therapeutic strategy because of its crucial role in cell growth and survival. This study …
therapeutic strategy because of its crucial role in cell growth and survival. This study …
Metal organic frameworks (MOFs) as potential anode materials for improving power generation from algal biophotovoltaic (BPV) platforms
CH Thong, N Priyanga, FL Ng, M Pappathi… - Catalysis Today, 2022 - Elsevier
Microalgae based biophotovoltaic (BPV) cells are substantiated as innovative renewable
energy generation devices, owing to their ability in mimicking the catalytic activity of …
energy generation devices, owing to their ability in mimicking the catalytic activity of …
Puerarin 6 ″‐O‐xyloside suppressed HCC via regulating proliferation, stemness, and apoptosis with inhibited PI3K/AKT/mTOR
L Li, JD Liu, GD Gao, K Zhang, YW Song… - Cancer …, 2020 - pmc.ncbi.nlm.nih.gov
Abstract Puerarin 6 ″‐O‐xyloside is a tumor suppressive derivate of Puerarin that is
recently characterized as a lysine‐specific demethylase 6B inhibitor. Here we investigated …
recently characterized as a lysine‐specific demethylase 6B inhibitor. Here we investigated …
PI3K and tankyrase inhibitors as therapeutic targets in colorectal cancer
ABSTRACT Introduction The pathways like Wingless-related integration (Wnt/β-catenin) and
PI3K play an important role in colorectal cancer (CRC) development; however, their roles …
PI3K play an important role in colorectal cancer (CRC) development; however, their roles …
[HTML][HTML] Synthesis, in-silico, and in-vitro study of novel chloro methylquinazolinones as PI3K-δ inhibitors, cytotoxic agents
SM Elfeky, SJ Almehmadi, SS Tawfik - Arabian Journal of Chemistry, 2022 - Elsevier
Through a two-step procedure, 3-amino-7-chloro-2-methylquinazolin-4 (3H)-one was
synthesized from 2-amino-4-chlorobenzoic acid as a starting material. The latter reacted with …
synthesized from 2-amino-4-chlorobenzoic acid as a starting material. The latter reacted with …
Important Roles of PI3K/AKT Signaling Pathway and Relevant Inhibitors in Prostate Cancer Progression
R Wang, Z Qu, Y Lv, L Yao, Y Qian, X Zhang… - Cancer …, 2024 - Wiley Online Library
Prostate cancer (PCa) is an extremely common malignant tumor of the male genitourinary
system, originating from the prostate gland epithelium. Male patients are prone to relapse …
system, originating from the prostate gland epithelium. Male patients are prone to relapse …