Measuring and modelling tumour heterogeneity across scales
GF Beeghly, AA Shimpi, RN Riter… - Nature Reviews …, 2023 - nature.com
Cancer development, progression and therapy response are heterogeneous and patient-
specific. The biological and physical properties of tumour cells and their surrounding tissue …
specific. The biological and physical properties of tumour cells and their surrounding tissue …
Recreating metabolic interactions of the tumour microenvironment
Tumours are heterogeneous tissues containing diverse populations of cells and an
abundant extracellular matrix (ECM). This tumour microenvironment prompts cancer cells to …
abundant extracellular matrix (ECM). This tumour microenvironment prompts cancer cells to …
Phosphoproteomic changes induced by cell-derived matrix and their effect on tumor cell migration and cytoskeleton remodeling
Increased fibrotic extracellular matrix (ECM) deposition promotes tumor invasion, which is
the first step of the metastatic cascade. Yet, the underlying mechanisms are poorly …
the first step of the metastatic cascade. Yet, the underlying mechanisms are poorly …
A microphysiological system reveals neutrophil contact-dependent attenuation of pancreatic tumor progression by CXCR2 inhibition-based immunotherapy
Cancer cells recruit neutrophils from the bloodstream into the tumor tissue, where these
immune cells promote the progression of numerous solid tumors. Studies in mice suggest …
immune cells promote the progression of numerous solid tumors. Studies in mice suggest …
Bridging systems biology and tissue engineering: Unleashing the full potential of complex 3D in vitro tissue models of disease
Rapid advances in tissue engineering have resulted in more complex and physiologically
relevant 3D in vitro tissue models with applications in fundamental biology and therapeutic …
relevant 3D in vitro tissue models with applications in fundamental biology and therapeutic …
[HTML][HTML] Endothelial cells metabolically regulate breast cancer invasion toward a microvessel
ML Tan, N Jenkins-Johnston, S Huang… - APL …, 2023 - pubs.aip.org
Breast cancer metastasis is initiated by invasion of tumor cells into the collagen type I-rich
stroma to reach adjacent blood vessels. Prior work has identified that metabolic plasticity is a …
stroma to reach adjacent blood vessels. Prior work has identified that metabolic plasticity is a …
[HTML][HTML] Advances in hyaluronic acid: Bioactivity, complexed biomaterials and biological application: A review
H Ye, R Zhang, C Zhang, Y Xia, L Jin - Asian Journal of Surgery, 2024 - Elsevier
Hyaluronic acid (HA) is a natural glycosaminoglycan found in the human body, particularly
in the extracellular matrix of body fluids and tissues. It plays a critical role in cellular …
in the extracellular matrix of body fluids and tissues. It plays a critical role in cellular …
Targeting glioblastoma tumor hyaluronan to enhance therapeutic interventions that regulate metabolic cell properties
E Neves, A Anand, J Mueller, R Remy, H Xu, K Selting… - bioRxiv, 2024 - biorxiv.org
Despite extensive advances in cancer research, glioblastoma (GBM) still remains a very
locally invasive and thus challenging tumor to treat, with a poor median survival. Tumor cells …
locally invasive and thus challenging tumor to treat, with a poor median survival. Tumor cells …
An Integrative Approach Towards Understanding Drivers of Tumor Cell Heterogeneity
A Shimpi - 2023 - search.proquest.com
Despite advancements in both treatment and detection, breast cancer remains the second
leading cause of cancer-related deaths in women. While breast cancer patients are often …
leading cause of cancer-related deaths in women. While breast cancer patients are often …