Bone degeneration associated with various diseases is increasing due to rapid aging,
sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical …

Approximately 40% of treatments of chronic and recurrent osteomyelitis fail in part due to
bacterial persistence. Staphylococcus aureus, the predominant pathogen in human …

Osteomyelitis caused by Staphylococcus aureus can involve the persistent infection of
osteocytes. We sought to determine if current clinically utilized antibiotics were capable of …

Infectious osteomyelitis associated with periprosthetic joint infections is often recalcitrant to
treatment and has a high rate of recurrence. In the case of Staphylococcus aureus, the most …

Examination of bacteria/host cell interactions is important for understanding the aetiology of
many infectious diseases. The colony forming unit (CFU) has been the standard for …

As the most numerous and long-lived of all bone cells, osteocytes have essential functions
in regulating skeletal health. Through the lacunar-canalicular system, secreted proteins from …

Cutibacterium acnes, part of normal skin flora, is increasingly recognized as an opportunistic
pathogen capable of causing chronic prosthetic joint infections (PJI) associated with total hip …

After periprosthetic joint infection (PJI)‐dependent revision surgery, a significantly elevated
number of patients suffer from prosthesis failure due to aseptic loosening and require …

The intracellular infection of osteocytes represents a clinically important aspect of
osteomyelitis. However, few human osteocyte in vitro models exist and the differentiation of …

Aims The management of periprosthetic joint infection (PJI) remains a major challenge in
orthopaedic surgery. In this study, we aimed to characterize the local bone microstructure …