Alkaline phosphatases (ALPs) are a group of isoenzymes, situated on the external layer of
the cell membrane; they catalyze the hydrolysis of organic phosphate esters present in the …

Sickle cell disease is an autosomal recessive disorder of the beta-globin gene, with resultant
deformation of the red blood cells and variable clinical outcomes. Nigeria is recognised as …

Background & Aims: Hepatic dysfunction in adults with sickle cell disease varies in character
and severity from self-limited cholestasis to life-threatening acute liver failure and cirrhosis …

Blood biochemistry has significant effect on pathophysiology of human body. Recently few
studies found the association of biochemical abnormalities in sickle cell patients. Sickle cell …

Abstract Background and Aims Previous studies have shown that supplementation of some
amino acids such as l‐arginine or its precursors could exert beneficial effects in patients with …

Background Sickle cell anemia (SCA) is a hereditary chronic hemolytic anemia with several
clinical consequences. Intravascular sickling of red blood cells leads to multi-organ …

BACKGROUND: Current adult guidelines for the management of choledocholithiasis (CDL)
may not be appropriate for children. We hypothesized adult preoperative predictive factors …

The effect of l-arginine on liver function in SCD has received little or no attention. The effect
of a chronic, oral, low-dose supplementation with l-arginine (1 gm/day for 6 weeks) on some …

Background Sickle cell disease (SCD) is a genetic blood disorder characterized by a painful
vaso-occlusive crisis due to the sickling of red blood cells in capillaries. Complications often …

Background Hepatic lesions in sickle cell disease were studied essentially in autopsy
specimens. We investigated chronic hepatopathy in living adults with sickle cell disease and …