Recent updates on mechanisms of resistance to 5-fluorouracil and reversal strategies in colon cancer treatment

S Azwar, HF Seow, M Abdullah, M Faisal Jabar… - Biology, 2021 - mdpi.com
Simple Summary Acquired resistance to chemotherapy by cancer cells is the predominant
factor in chemotherapy failure, which ultimately leads to disease progression and death …

ATP‐binding cassette (ABC) transporters in cancer: A review of recent updates

JQ Wang, ZX Wu, Y Yang, QX Teng… - Journal of Evidence …, 2021 - Wiley Online Library
The ATP‐binding cassette (ABC) transporter superfamily is one of the largest membrane
protein families existing in wide spectrum of organisms from prokaryotes to human. ABC …

Long non-coding RNA H19 confers 5-Fu resistance in colorectal cancer by promoting SIRT1-mediated autophagy

M Wang, D Han, Z Yuan, H Hu, Z Zhao, R Yang… - Cell death & …, 2018 - nature.com
Chemotherapy failure is the major cause of recurrence and poor prognosis in colorectal
cancer (CRC) patients. The role of the differentially expressed lncRNAs in 5-Fluorouracil …

LncRNA NEAT1 remodels chromatin to promote the 5-Fu resistance by maintaining colorectal cancer stemness

Y Zhu, H Hu, Z Yuan, Q Zhang, H Xiong, Z Hu… - Cell Death & …, 2020 - nature.com
Resistance of chemotherapy is one of causes of recurrence and poor prognosis in patients
with colorectal cancer (CRC). The role of differentially expressed long non-coding RNA …

[HTML][HTML] ABCB4 disease: Many faces of one gene deficiency

E Sticova, M Jirsa - Annals of Hepatology, 2020 - Elsevier
ATP-binding cassette (ABC) subfamily B member 4 (ABCB4), also known as multidrug
resistance protein 3 (MDR3), encoded by ABCB4, is involved in biliary phospholipid …

Decoding the methylation patterns of ABC transporters in colorectal cancer

NN Norhisan, R Baharudin… - … In Microbes & …, 2024 - journals.hh-publisher.com
Colorectal cancer (CRC) is a significant global health concern, posing a major threat to
morbidity and mortality rates. The molecular mechanisms that drive CRC, particularly the …

A novel lipid metabolism gene signature for clear cell renal cell carcinoma using integrated bioinformatics analysis

K Li, Y Zhu, J Cheng, A Li, Y Liu, X Yang… - Frontiers in Cell and …, 2023 - frontiersin.org
Background: Clear cell renal cell carcinoma (ccRCC), which is the most prevalent type of
renal cell carcinoma, has a high mortality rate. Lipid metabolism reprogramming is a …

Long noncoding RNA TMPO-AS1 accelerates glycolysis by regulating the miR-1270/PKM2 axis in colorectal cancer

Y Jin, A Jiang, L Sun, Y Lu - BMC cancer, 2024 - Springer
Background Long noncoding RNA thymopoietin-antisense RNA 1 (TMPO-AS1) is
recognized as a participant in cancer progression. Nevertheless, its biological function in …

The role of ATP-binding cassette subfamily A in colorectal cancer progression and resistance

L Alketbi, A Al-Ali, IM Talaat, Q Hamid… - International Journal of …, 2023 - mdpi.com
Colorectal cancer (CRC) is one of the most common malignancies worldwide; it is the fourth
leading cause of cancer-related deaths. CRC arises due to mutations that can affect …

The clinical relevance and prediction efficacy from therapy of tumor microenvironment related signature score in colorectal cancer

X Jun, S Gao, L Yu, G Wang - Frontiers in Oncology, 2023 - frontiersin.org
Introduction As the top 3 cancer in terms of incidence and mortality, the first-line treatment for
CRC includes FOLFOX, FOLFIRI, Cetuximab or immunotherapy. However, the drug …