1H-Detected Biomolecular NMR under Fast Magic-Angle Spinning

T Le Marchand, T Schubeis, M Bonaccorsi… - Chemical …, 2022 - ACS Publications
Since the first pioneering studies on small deuterated peptides dating more than 20 years
ago, 1H detection has evolved into the most efficient approach for investigation of …

Biomolecular and biological applications of solid-state NMR with dynamic nuclear polarization enhancement

WY Chow, G De Paëpe, S Hediger - Chemical Reviews, 2022 - ACS Publications
Solid-state NMR spectroscopy (ssNMR) with magic-angle spinning (MAS) enables the
investigation of biological systems within their native context, such as lipid membranes, viral …

Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain

R Kumar, T Le Marchand, L Adam, R Bobrovs… - Nature …, 2024 - nature.com
Protein misfolding can generate toxic intermediates, which underlies several devastating
diseases, such as Alzheimer's disease (AD). The surface of AD-associated amyloid-β …

PyrroTriPol: a semi-rigid trityl-nitroxide for high field dynamic nuclear polarization

T Halbritter, R Harrabi, S Paul, J van Tol, D Lee… - Chemical …, 2023 - pubs.rsc.org
Magic angle spinning (MAS) dynamic nuclear polarization (DNP) has significantly
broadened the scope of solid-state NMR to study biomolecular systems and materials. In …

Role of conformational dynamics in pathogenic protein aggregation

X Sun, HJ Dyson, PE Wright - Current opinion in chemical biology, 2023 - Elsevier
The accumulation of pathogenic protein oligomers and aggregates is associated with
several devastating amyloid diseases. As protein aggregation is a multi-step nucleation …

Resonant mixing dynamic nuclear polarization

Y Quan, Y Ouyang, M Mardini, RS Palani… - The Journal of …, 2023 - ACS Publications
We propose a mechanism for dynamic nuclear polarization that is different from the well-
known Overhauser effect, solid effect, cross effect, and thermal mixing processes. We term it …

Characterization of dielectric properties and their impact on MAS-DNP NMR applications

FJ Scott, T Dubroca, RW Schurko, S Hill… - Journal of Magnetic …, 2024 - Elsevier
The dielectric properties of materials play a crucial role in the propagation and absorption of
microwave beams employed in Magic Angle Spinning− Dynamic Nuclear Polarization (MAS …

Amplified overhauser DNP with selective deuteration: attenuation of double-quantum cross-relaxation

RS Palani, M Mardini, L Delage-Laurin… - The journal of …, 2022 - ACS Publications
We recently used selective 2H labeling of BDPA to investigate the Overhauser Effect (OE)
dynamic nuclear polarization (DNP) mechanism in insulating solids doped with 1, 3-bis …

Dipolar Recoupling in Rotating Solids

V Ladizhansky, RS Palani, M Mardini… - Chemical …, 2024 - ACS Publications
Magic angle spinning (MAS) nuclear magnetic resonance (NMR) has evolved significantly
over the past three decades and established itself as a vital tool for the structural analysis of …

Diamond rotors

NC Golota, ZP Fredin, DP Banks, D Preiss… - Journal of Magnetic …, 2023 - Elsevier
The resolution of magic angle spinning (MAS) nuclear magnetic resonance (NMR) spectra
remains bounded by the spinning frequency, which is limited by the material strength of MAS …